General Information:

Id: 1,513
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
male
article
Reference: Baur JA et al.(2006) Resveratrol improves health and survival of mice on a high-calorie diet Nature 444: 337-342 [PMID: 17086191]

Interaction Information:

Comment Resveratrol (3,5,4'-trihydroxystilbene) shifts the physiology of middle-aged mice on a high-calorie diet towards that of mice on a standard diet and significantly increases their survival. Resveratrol produces changes associated with longer lifespan, including increased insulin sensitivity, reduced insulin-like growth factor-1 (IGF-I) levels, increased AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) activity, increased mitochondrial number, and improved motor function.
Formal Description
Interaction-ID: 10707

drug/chemical compound

Resveratrol

increases_activity of

in mice on high-calorie diet
Drugbank entries Show/Hide entries for Resveratrol
Comment Resveratrol (3,5,4'-trihydroxystilbene) shifts the physiology of middle-aged mice on a high-calorie diet towards that of mice on a standard diet and significantly increases their survival. Resveratrol produces changes associated with longer lifespan, including increased insulin sensitivity, reduced insulin-like growth factor-1 (IGF-I) levels, increased AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) activity, increased mitochondrial number, and improved motor function.
Formal Description
Interaction-ID: 10710

drug/chemical compound

Resveratrol

decreases_quantity of

gene/protein

IGF1

in mice on high-calorie diet
Drugbank entries Show/Hide entries for Resveratrol or IGF1
Comment Resveratrol (3,5,4'-trihydroxystilbene) shifts the physiology of middle-aged mice on a high-calorie diet towards that of mice on a standard diet and significantly increases their survival. Resveratrol produces changes associated with longer lifespan, including increased insulin sensitivity, reduced insulin-like growth factor-1 (IGF-I) levels, increased AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) activity, increased mitochondrial number, and improved motor function.
Formal Description
Interaction-ID: 10711

drug/chemical compound

Resveratrol

increases_activity of

complex/PPI

AMPK

in mice on high-calorie diet
Drugbank entries Show/Hide entries for Resveratrol
Comment Resveratrol (3,5,4'-trihydroxystilbene) shifts the physiology of middle-aged mice on a high-calorie diet towards that of mice on a standard diet and significantly increases their survival. Resveratrol produces changes associated with longer lifespan, including increased insulin sensitivity, reduced insulin-like growth factor-1 (IGF-I) levels, increased AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) activity, increased mitochondrial number, and improved motor function.
Formal Description
Interaction-ID: 10714

drug/chemical compound

Resveratrol

increases_activity of

gene/protein

PPARGC1A

in mice on high-calorie diet
Drugbank entries Show/Hide entries for Resveratrol
Comment Resveratrol (3,5,4'-trihydroxystilbene) shifts the physiology of middle-aged mice on a high-calorie diet towards that of mice on a standard diet and significantly increases their survival. Resveratrol produces changes associated with longer lifespan, including increased insulin sensitivity, reduced insulin-like growth factor-1 (IGF-I) levels, increased AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) activity, increased mitochondrial number, and improved motor function.
Formal Description
Interaction-ID: 10716

drug/chemical compound

Resveratrol

increases_quantity of

cellular component

mitochondrion

in mice on high-calorie diet
Drugbank entries Show/Hide entries for Resveratrol
Comment In the resveratrol-fed group the most highly downregulated pathways included: insulin signalling, mTOR and IGF-1 signalling, oxidative phosphorylation and electron transport.
Formal Description
Interaction-ID: 10724

drug/chemical compound

Resveratrol

decreases_activity of

in mice on high-calorie diet
Drugbank entries Show/Hide entries for Resveratrol
Comment In the resveratrol-fed group the most highly downregulated pathways included: insulin signalling, mTOR and IGF-1 signalling, oxidative phosphorylation and electron transport.
Formal Description
Interaction-ID: 10727

drug/chemical compound

Resveratrol

decreases_activity of

process

TOR signaling

in mice on high-calorie diet
Drugbank entries Show/Hide entries for Resveratrol
Comment In the resveratrol-fed group the most highly downregulated pathways included: insulin signalling, mTOR and IGF-1 signalling, oxidative phosphorylation and electron transport.
Formal Description
Interaction-ID: 10732

drug/chemical compound

Resveratrol

decreases_activity of

in mice on high-calorie diet
Drugbank entries Show/Hide entries for Resveratrol
Comment In the resveratrol-fed group the most highly downregulated pathways included: insulin signalling, mTOR and IGF-1 signalling, oxidative phosphorylation and electron transport.
Formal Description
Interaction-ID: 10734

drug/chemical compound

Resveratrol

decreases_activity of

in mice on high-calorie diet
Drugbank entries Show/Hide entries for Resveratrol
Comment Pathways altered in the same direction by caloric restriction and resveratrol included the downregulation of IGF-1 and mTOR signalling, downregulation of glycolysis, and upregulation of Stat3 signalling.
Formal Description
Interaction-ID: 10736

drug/chemical compound

Resveratrol

decreases_activity of

in mice on high-calorie diet
Drugbank entries Show/Hide entries for Resveratrol
Comment Pathways altered in the same direction by caloric restriction and resveratrol included the downregulation of IGF-1 and mTOR signalling, downregulation of glycolysis, and upregulation of Stat3 signalling.
Formal Description
Interaction-ID: 10737

drug/chemical compound

Resveratrol

increases_activity of

process

STAT3 signaling pathway

in mice on high-calorie diet
Drugbank entries Show/Hide entries for Resveratrol