General Information:

Id: 151
Diseases: Amyotrophic lateral sclerosis
Mammalia
BTO:0001976 Neuro-2a cell
article
Reference: Oh YK et al.(2008) Superoxide dismutase 1 mutants related to amyotrophic lateral sclerosis induce endoplasmic stress in neuro2a cells J. Neurochem. 104: 993-1005 [PMID: 18233996]

Interaction Information:

Comment The kinase PERK was more strongly phosphorylated in the mutant-expressing cells when compared with the wild type-expressing cells.
Formal Description
Interaction-ID: 568

gene/protein mutant

SOD1-p.G85R

increases_phosphorylation of

gene/protein

EIF2AK3

if mutant SOD1 is over-expressed
Comment The kinase PERK was more strongly phosphorylated in the mutant-expressing cells when compared with the wild type-expressing cells.
Formal Description
Interaction-ID: 572

gene/protein mutant

SOD1-p.G93A

increases_phosphorylation of

gene/protein

EIF2AK3

if mutant SOD1 is over-expressed
Comment eIF-2-alpha was more strongly phosphorylated in the mutant-expressing cells when compared with the wild type-expressing cells.
Formal Description
Interaction-ID: 573

gene/protein mutant

SOD1-p.G85R

increases_phosphorylation of

gene/protein

EIF2S1

if mutant SOD1 is over-expressed
Comment eIF-2-alpha was more strongly phosphorylated in the mutant-expressing cells when compared with the wild type-expressing cells.
Formal Description
Interaction-ID: 576

gene/protein mutant

SOD1-p.G93A

increases_phosphorylation of

gene/protein

EIF2S1

if mutant SOD1 is over-expressed
Comment The kinase JNK was more strongly phosphorylated in the mutant-expressing cells when compared with the wild type-expressing cells.
Formal Description
Interaction-ID: 582

gene/protein mutant

SOD1-p.G85R

increases_phosphorylation of

gene/protein

MAPK8

if mutant SOD1 is over-expressed
Drugbank entries Show/Hide entries for MAPK8
Comment The kinase JNK was more strongly phosphorylated in the mutant-expressing cells when compared with the wild type-expressing cells.
Formal Description
Interaction-ID: 585

gene/protein mutant

SOD1-p.G93A

increases_phosphorylation of

gene/protein

MAPK8

if mutant SOD1 is over-expressed
Drugbank entries Show/Hide entries for MAPK8
Comment Expression of the mutant SOD1 caused signs of both early and late ER stress responses.
Formal Description
Interaction-ID: 587

gene/protein mutant

SOD1-p.G85R

increases_activity of

if mutant SOD1 is over-expressed
Comment Mutant SOD1 induced cleavage of ATF6 into 50 kDa fragments and its translocation into the nucleus when compared with the wild type-expressing cells.
Formal Description
Interaction-ID: 598

gene/protein mutant

SOD1-p.G85R

increases_transport of

gene/protein

ATF6

into nucleus; if mutant SOD1 is over-expressed
Comment Mutant SOD1 induced cleavage of ATF6 into 50 kDa fragments and its translocation into the nucleus when compared with the wild type-expressing cells.
Formal Description
Interaction-ID: 601

gene/protein mutant

SOD1-p.G93A

increases_transport of

gene/protein

ATF6

into nucleus; if mutant SOD1 is over-expressed
Comment The level of BiP/Grp78 slightly but consistently increased in the mutant SOD1-expressing cells compared with wild type-expressing cells.
Formal Description
Interaction-ID: 610

gene/protein mutant

SOD1-p.G85R

increases_expression of

gene/protein

HSPA5

if mutant SOD1 is over-expressed
Drugbank entries Show/Hide entries for HSPA5
Comment The level of BiP/Grp78 slightly but consistently increased in the mutant SOD1-expressing cells compared with wild type-expressing cells.
Formal Description
Interaction-ID: 611

gene/protein mutant

SOD1-p.G93A

increases_expression of

gene/protein

HSPA5

if mutant SOD1 is over-expressed
Drugbank entries Show/Hide entries for HSPA5
Comment The level of the cell death regulators changed in the mutant SOD1-expressing cells. The level of Bcl-2 slightly decreased, the level of Bax increased during transfection.
Formal Description
Interaction-ID: 612

gene/protein mutant

SOD1-p.G85R

decreases_expression of

gene/protein

BCL2

if mutant SOD1 is over-expressed
Drugbank entries Show/Hide entries for BCL2
Comment The level of the cell death regulators changed in the mutant SOD1-expressing cells. The level of Bcl-2 slightly decreased, the level of Bax increased during transfection.
Formal Description
Interaction-ID: 613

gene/protein mutant

SOD1-p.G93A

decreases_expression of

gene/protein

BCL2

if mutant SOD1 is over-expressed
Drugbank entries Show/Hide entries for BCL2
Comment The level of the cell death regulators changed in the mutant SOD1-expressing cells. The level of Bcl-2 slightly decreased, the level of Bax increased during transfection.
Formal Description
Interaction-ID: 614

gene/protein mutant

SOD1-p.G93A

increases_expression of

gene/protein

BAX

if mutant SOD1 is over-expressed
Comment The level of the cell death regulators changed in the mutant SOD1-expressing cells. The level of Bcl-2 slightly decreased, the level of Bax increased during transfection.
Formal Description
Interaction-ID: 615

gene/protein mutant

SOD1-p.G85R

increases_expression of

gene/protein

BAX

if mutant SOD1 is over-expressed
Comment The activation of caspase 12 and 7 was detected in the mutant-SOD1 over-expressing cells.
Formal Description
Interaction-ID: 624

gene/protein mutant

SOD1-p.G85R

increases_activity of

gene/protein

CASP12

if mutant SOD1 is over-expressed
Comment The activation of caspase 12 and 7 was detected in the mutant-SOD1 over-expressing cells.
Formal Description
Interaction-ID: 629

gene/protein mutant

SOD1-p.G93A

increases_activity of

gene/protein

CASP12

if mutant SOD1 is over-expressed
Comment The activation of caspase 12 and 7 was detected in the mutant-SOD1 over-expressing cells.
Formal Description
Interaction-ID: 630

gene/protein mutant

SOD1-p.G85R

increases_activity of

gene/protein

CASP7

if mutant SOD1 is over-expressed
Drugbank entries Show/Hide entries for CASP7
Comment The activation of caspase 12 and 7 was detected in the mutant-SOD1 over-expressing cells.
Formal Description
Interaction-ID: 631

gene/protein mutant

SOD1-p.G93A

increases_activity of

gene/protein

CASP7

if mutant SOD1 is over-expressed
Drugbank entries Show/Hide entries for CASP7
Comment Mutant SOD1 induced caspase -activated apoptosis.
Formal Description
Interaction-ID: 642

gene/protein mutant

SOD1-p.G85R

increases_activity of

if mutant SOD1 is over-expressed
Comment Mutant SOD1 induced caspase -activated apoptosis.
Formal Description
Interaction-ID: 644

gene/protein mutant

SOD1-p.G93A

increases_activity of

if mutant SOD1 is over-expressed
Comment Salubrinal protected the cells from the mutant SOD1-induced death by suppressing the UPR (unfolded protein response) propagating into death signaling.
Formal Description
Interaction-ID: 645

drug/chemical compound

Salubrinal

decreases_activity of

if mutant SOD1 (G85R or G93A) is over-expressed
Comment Salubrinal inhibited the activation of caspase 12 in mutant SOD1 induced cells.
Formal Description
Interaction-ID: 654

drug/chemical compound

Salubrinal

decreases_activity of

gene/protein

CASP12

if mutant SOD1 (G85R or G93A) is over-expressed