General Information:

Id: 1,508 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mus musculus
Reference: Solinas G et al.(2006) Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates Proc. Natl. Acad. Sci. U.S.A. 103 [PMID: 17050683]

Interaction Information:

Comment In pancreatic beta-cells palmitic acid treatment inhibits glucose-induced insulin gene transcription, in part, by interfering with autocrine insulin signaling through phosphorylation of insulin-receptor substrates 1 and 2 at sites that interfere with binding to activated insulin receptors.
Formal Description
Interaction-ID: 10670

drug/chemical compound

Palmitic acid

decreases_activity of

in pancreas, in pancreatic beta cells
Drugbank entries Show/Hide entries for Palmitic acid