General Information:

Id: 1,504 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
BTO:0000991 pancreatic islet
article
Reference: Zeender E et al.(2004) Pioglitazone and sodium salicylate protect human beta-cells against apoptosis and impaired function induced by glucose and interleukin-1beta J. Clin. Endocrinol. Metab. 89: 5059-5066 [PMID: 15472206]

Interaction Information:

Comment The thiazolidinedione (glitazone) pioglitazone and the nonsteroidal antiinflammatory drug sodium salicylate protected partially against loss of glucose-stimulated insulin secretion and prevented completely increased apoptosis caused by IL-1beta or 600 mg/dl glucose.
Formal Description
Interaction-ID: 10654

drug/chemical compound

Pioglitazone

affects_activity of

in pancreas, in pancreatic islets; if IL1B or glucose is increased
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