General Information:

Id: 1,504 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
BTO:0000991 pancreatic islet
article
Reference: Zeender E et al.(2004) Pioglitazone and sodium salicylate protect human beta-cells against apoptosis and impaired function induced by glucose and interleukin-1beta J. Clin. Endocrinol. Metab. 89: 5059-5066 [PMID: 15472206]

Interaction Information:

Comment Human islets were maintained in culture 2-4 d at 100 mg/dl glucose with or without (control) IL-1beta or at 600 mg/dl glucose. IL-1beta and 600 mg/dl glucose increased beta-cell apoptosis and abolished short-term glucose-stimulated insulin secretion.
Formal Description
Interaction-ID: 10652

gene/protein

IL1B

decreases_activity of

in pancreas, in pancreatic islets
Drugbank entries Show/Hide entries for IL1B