General Information:

Id: 1,504
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
BTO:0000991 pancreatic islet
article
Reference: Zeender E et al.(2004) Pioglitazone and sodium salicylate protect human beta-cells against apoptosis and impaired function induced by glucose and interleukin-1beta J. Clin. Endocrinol. Metab. 89: 5059-5066 [PMID: 15472206]

Interaction Information:

Comment Human islets were maintained in culture 2-4 d at 100 mg/dl glucose with or without (control) IL-1beta or at 600 mg/dl glucose. IL-1beta and 600 mg/dl glucose increased beta-cell apoptosis and abolished short-term glucose-stimulated insulin secretion.
Formal Description
Interaction-ID: 10637

gene/protein

IL1B

increases_activity of

in pancreas, in pancreatic islets
Drugbank entries Show/Hide entries for IL1B
Comment Human islets were maintained in culture 2-4 d at 100 mg/dl glucose with or without (control) IL-1beta or at 600 mg/dl glucose. IL-1beta and 600 mg/dl glucose increased beta-cell apoptosis and abolished short-term glucose-stimulated insulin secretion.
Formal Description
Interaction-ID: 10652

gene/protein

IL1B

decreases_activity of

in pancreas, in pancreatic islets
Drugbank entries Show/Hide entries for IL1B
Comment The thiazolidinedione (glitazone) pioglitazone and the nonsteroidal antiinflammatory drug sodium salicylate protected partially against loss of glucose-stimulated insulin secretion and prevented completely increased apoptosis caused by IL-1beta or 600 mg/dl glucose.
Formal Description
Interaction-ID: 10654

drug/chemical compound

Pioglitazone

affects_activity of

in pancreas, in pancreatic islets; if IL1B or glucose is increased
Drugbank entries Show/Hide entries for Pioglitazone
Comment The thiazolidinedione (glitazone) pioglitazone and the nonsteroidal antiinflammatory drug sodium salicylate protected partially against loss of glucose-stimulated insulin secretion and prevented completely increased apoptosis caused by IL-1beta or 600 mg/dl glucose.
Formal Description
Interaction-ID: 10655

drug/chemical compound

Sodium salicylate

affects_activity of

in pancreas, in pancreatic islets; if IL1B or glucose is increased
Comment The thiazolidinedione (glitazone) pioglitazone and the nonsteroidal antiinflammatory drug sodium salicylate protected partially against loss of glucose-stimulated insulin secretion and prevented completely increased apoptosis caused by IL-1beta or 600 mg/dl glucose.
Formal Description
Interaction-ID: 10656

drug/chemical compound

Pioglitazone

affects_activity of

in pancreas, in pancreatic islets; if IL1B or glucose is increased
Drugbank entries Show/Hide entries for Pioglitazone
Comment The thiazolidinedione (glitazone) pioglitazone and the nonsteroidal antiinflammatory drug sodium salicylate protected partially against loss of glucose-stimulated insulin secretion and prevented completely increased apoptosis caused by IL-1beta or 600 mg/dl glucose.
Formal Description
Interaction-ID: 10657

drug/chemical compound

Sodium salicylate

affects_activity of

in pancreas, in pancreatic islets; if IL1B or glucose is increased
Comment IL-1beta release from islets was increased 4.4-fold by high glucose, and this increase was prevented completely by pioglitazone. No significant effect of sodium salicylate on IL-1beta secretion was observed at either low or high glucos.
Formal Description
Interaction-ID: 10658

drug/chemical compound

Glucose

increases_activity of

in pancreas, in pancreatic islets
Comment IL-1beta release from islets was increased 4.4-fold by high glucose, and this increase was prevented completely by pioglitazone. No significant effect of sodium salicylate on IL-1beta secretion was observed at either low or high glucose.
Formal Description
Interaction-ID: 10659

drug/chemical compound

Pioglitazone

affects_activity of

in pancreas, in pancreatic islets; if glucose level is high
Drugbank entries Show/Hide entries for Pioglitazone
Comment IL-1beta release from islets was increased 4.4-fold by high glucose, and this increase was prevented completely by pioglitazone. No significant effect of sodium salicylate on IL-1beta secretion was observed at either low or high glucose.
Formal Description
Interaction-ID: 10660

drug/chemical compound

Sodium salicylate

NOT affects_activity of

in pancreas, in pancreatic islets
Comment Pioglitazone and sodium salicylate prevented activation of beta-cell NFkappaB by high glucose.
Formal Description
Interaction-ID: 10661

drug/chemical compound

Glucose

increases_activity of

complex/PPI

NF-kappaB complex

in pancreas, in pancreatic beta cells
Comment Pioglitazone and sodium salicylate prevented activation of beta-cell NFkappaB by high glucose.
Formal Description
Interaction-ID: 10662

drug/chemical compound

Pioglitazone

affects_activity of

complex/PPI

NF-kappaB complex

in pancreas, in pancreatic beta cells; if glucose level is high
Drugbank entries Show/Hide entries for Pioglitazone
Comment Pioglitazone and sodium salicylate prevented activation of beta-cell NFkappaB by high glucose.
Formal Description
Interaction-ID: 10663

drug/chemical compound

Sodium salicylate

affects_activity of

complex/PPI

NF-kappaB complex

in pancreas, in pancreatic beta cells; if glucose level is high