General Information:

Id: 1,492 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
article
Reference: Maedler K et al.(2008) Glucose and leptin induce apoptosis in human beta-cells and impair glucose-stimulated insulin secretion through activation of c-Jun N-terminal kinases FASEB J. 22: 1905-1913 [PMID: 18263705]

Interaction Information:

Comment Exposure of human islets to leptin and high glucose concentrations leads to a decrease of glucose-induced insulin secretion, which was partly restored by JNKi.
Formal Description
Interaction-ID: 10536

phenotype

increased leptin level

decreases_activity of

process

insulin secretion

in pancreas, in pancreatic islets