General Information:
Id: | 1,492 (click here to show other Interactions for entry) |
Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
Homo sapiens | |
article | |
Reference: | Maedler K et al.(2008) Glucose and leptin induce apoptosis in human beta-cells and impair glucose-stimulated insulin secretion through activation of c-Jun N-terminal kinases FASEB J. 22: 1905-1913 [PMID: 18263705] |
Interaction Information:
Comment | Exposure of human islets to leptin and high glucose concentrations leads to a decrease of glucose-induced insulin secretion, which was partly restored by JNKi. |
Formal Description Interaction-ID: 10536 |
phenotype increased leptin level decreases_activity of process |