General Information:

Id: 147 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Homo sapiens
BTO:0000793 SH-SY5Y cell
article
Reference: Shiba K et al.(2009) Parkin stabilizes PINK1 through direct interaction. Biochem. Biophys. Res. Commun. 383: 331-335 [PMID: 19358826]

Interaction Information:

Comment Parkin stabilizes PINK1 protein by inhibiting its ubiquitination and concomitant ubiquitin-mediated proteasomal degradation. Parkin does not stabilize the proteins of pathogenic PINK1 mutants (H271Q, G309D, E417G) due to the loss of their binding activities wisth Parkin.
Formal Description
Interaction-ID: 541

gene/protein

PARK2

NOT decreases_ubiquitination/sumoylation of

gene/protein mutant

PINK1-p.G309D