General Information:

Id: 1,475 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Rattus norvegicus
BTO:0000312 motoneuron
Reference: Tovar-Y-Romo LB and Tapia R(2010) VEGF protects spinal motor neurons against chronic excitotoxic degeneration in vivo by activation of PI3-K pathway and inhibition of p38MAPK J. Neurochem. 115: 1090-1101 [PMID: 20456006]

Interaction Information:

Comment Infusion of AMPA (alpha-amino-3- hydroxy-5-isoxazolepropionate) in the rat lumbar spinal cord leads to motor neuron death and concomitantly paralysis of the rear limbs.
Formal Description
Interaction-ID: 10401

drug/chemical compound


increases_activity of

Drugbank entries Show/Hide entries for AMPA
Comment When 20 mM SU1498, a selective VEGFR2 inhibitor (KDR), was infused in addition to AMPA + VEGF, all treated rats (n = 6) displayed motor alterations that began with flexion of the ipsilateral hindlimb and progressed to a rigid extension of both hindlimbs as soon as 2 days after surgery; by day 7, the posterior train of all rats was fully paralyzed, causing notable rotarod, PGE, and stride deficits.
Formal Description
Interaction-ID: 10405



decreases_activity of

Drugbank entries Show/Hide entries for KDR