General Information:

Id: 147
Diseases: Parkinson disease
Homo sapiens
BTO:0000793 SH-SY5Y cell
article
Reference: Shiba K et al.(2009) Parkin stabilizes PINK1 through direct interaction. Biochem. Biophys. Res. Commun. 383: 331-335 [PMID: 19358826]

Interaction Information:

Comment Parkin stabilizes PINK1 through direct interaction.
Formal Description
Interaction-ID: 531

gene/protein

PARK2

interacts (colocalizes) with

gene/protein

PINK1

Comment Pathogenic Parkin mutants (Parkin-K161N, -T240R, -T415N, and -G430D) interact with PINK1, but do not stabilize PINK1 protein.
Formal Description
Interaction-ID: 532

gene/protein mutant

PARK2-p.K161N

interacts (colocalizes) with

gene/protein

PINK1

Comment Pathogenic Parkin mutants (Parkin-K161N, -T240R, -T415N, and -G430D) interact with PINK1, but do not stabilize PINK1 protein.
Formal Description
Interaction-ID: 533

gene/protein mutant

PARK2-p.T240R

interacts (colocalizes) with

gene/protein

PINK1

Comment Pathogenic Parkin mutants (Parkin-K161N, -T240R, -T415N, and -G430D) interact with PINK1, but do not stabilize PINK1 protein.
Formal Description
Interaction-ID: 534

gene/protein mutant

PARK2-p.T415N

interacts (colocalizes) with

gene/protein

PINK1

Comment Pathogenic Parkin mutants (Parkin-K161N, -T240R, -T415N, and -G430D) interact with PINK1, but do not stabilize PINK1 protein.
Formal Description
Interaction-ID: 535

gene/protein mutant

PARK2-p.G430D

interacts (colocalizes) with

gene/protein

PINK1

Comment Parkin does not interact with the pathogenic PINK1 mutants H271Q, G309D and E417G.
Formal Description
Interaction-ID: 536

gene/protein

PARK2

NOT interacts (colocalizes) with

gene/protein mutant

PINK1-p.H271Q

Comment Parkin does not interact with the pathogenic PINK1 mutants H271Q, G309D and E417G.
Formal Description
Interaction-ID: 537

gene/protein

PARK2

NOT interacts (colocalizes) with

gene/protein mutant

PINK1-p.G309D

Comment Parkin does not interact with the pathogenic PINK1 mutants H271Q, G309D and E417G.
Formal Description
Interaction-ID: 538

gene/protein

PARK2

NOT interacts (colocalizes) with

gene/protein mutant

PINK1-p.E417G

Comment Parkin stabilizes PINK1 protein by inhibiting its ubiquitination and concomitant ubiquitin-mediated proteasomal degradation. Parkin does not stabilize the proteins of pathogenic PINK1 mutants (H271Q, G309D, E417G) due to the loss of their binding activities wisth Parkin.
Formal Description
Interaction-ID: 539

gene/protein

PARK2

decreases_ubiquitination/sumoylation of

gene/protein

PINK1

Comment Parkin stabilizes PINK1 protein by inhibiting its ubiquitination and concomitant ubiquitin-mediated proteasomal degradation. Parkin does not stabilize the proteins of pathogenic PINK1 mutants (H271Q, G309D, E417G) due to the loss of their binding activities wisth Parkin.
Formal Description
Interaction-ID: 540

gene/protein

PARK2

NOT decreases_ubiquitination/sumoylation of

gene/protein mutant

PINK1-p.H271Q

Comment Parkin stabilizes PINK1 protein by inhibiting its ubiquitination and concomitant ubiquitin-mediated proteasomal degradation. Parkin does not stabilize the proteins of pathogenic PINK1 mutants (H271Q, G309D, E417G) due to the loss of their binding activities wisth Parkin.
Formal Description
Interaction-ID: 541

gene/protein

PARK2

NOT decreases_ubiquitination/sumoylation of

gene/protein mutant

PINK1-p.G309D

Comment Parkin stabilizes PINK1 protein by inhibiting its ubiquitination and concomitant ubiquitin-mediated proteasomal degradation. Parkin does not stabilize the proteins of pathogenic PINK1 mutants (H271Q, G309D, E417G) due to the loss of their binding activities wisth Parkin.
Formal Description
Interaction-ID: 542

gene/protein

PARK2

NOT decreases_ubiquitination/sumoylation of

gene/protein mutant

PINK1-p.E417G

Comment Pathogenic Parkin mutants, Parkin-K161N, T240R, T415N, G430D or C418G, did not interfere with the ubiquitination of PINK1.
Formal Description
Interaction-ID: 543

gene/protein mutant

PARK2-p.K161N

NOT decreases_ubiquitination/sumoylation of

gene/protein

PINK1

Comment Pathogenic Parkin mutants, Parkin-K161N, T240R, T415N, G430D or C418G, did not interfere with the ubiquitination of PINK1.
Formal Description
Interaction-ID: 544

gene/protein mutant

PARK2-p.T240R

NOT decreases_ubiquitination/sumoylation of

gene/protein

PINK1

Comment Pathogenic Parkin mutants, Parkin-K161N, T240R, T415N, G430D or C418G, did not interfere with the ubiquitination of PINK1.
Formal Description
Interaction-ID: 545

gene/protein mutant

PARK2-p.T415N

NOT decreases_ubiquitination/sumoylation of

gene/protein

PINK1

Comment Pathogenic Parkin mutants, Parkin-K161N, T240R, T415N, G430D or C418G, did not interfere with the ubiquitination of PINK1.
Formal Description
Interaction-ID: 546

gene/protein mutant

PARK2-p.G430D

NOT decreases_ubiquitination/sumoylation of

gene/protein

PINK1

Comment Pathogenic Parkin mutants, Parkin-K161N, T240R, T415N, G430D or C418G, did not interfere with the ubiquitination of PINK1.
Formal Description
Interaction-ID: 547

gene/protein mutant

PARK2-p.C418G

NOT increases_ubiquitination/sumoylation of

gene/protein

PINK1

Comment Parkin stabilizes PINK1 protein by inhibiting its ubiquitination and concomitant ubiquitin-mediated proteasomal degradation. Parkin does not stabilize the proteins of pathogenic PINK1 mutants (H271Q, G309D, E417G) due to the loss of their binding activities wisth Parkin.
Formal Description
Interaction-ID: 9363

gene/protein

PARK2

increases_quantity of

gene/protein

PINK1

by inhibiting its ubiquitin-mediated proteasomal degradation
Comment Parkin stabilizes PINK1 protein by inhibiting its ubiquitination and concomitant ubiquitin-mediated proteasomal degradation. Parkin does not stabilize the proteins of pathogenic PINK1 mutants (H271Q, G309D, E417G) due to the loss of their binding activities wisth Parkin.
Formal Description
Interaction-ID: 9364

gene/protein

PARK2

NOT increases_quantity of

gene/protein mutant

PINK1-p.H271Q

by inhibiting its ubiquitin-mediated proteasomal degradation
Comment Parkin stabilizes PINK1 protein by inhibiting its ubiquitination and concomitant ubiquitin-mediated proteasomal degradation. Parkin does not stabilize the proteins of pathogenic PINK1 mutants (H271Q, G309D, E417G) due to the loss of their binding activities wisth Parkin.
Formal Description
Interaction-ID: 9365

gene/protein

PARK2

NOT increases_quantity of

gene/protein mutant

PINK1-p.G309D

by inhibiting its ubiquitin-mediated proteasomal degradation
Comment Parkin stabilizes PINK1 protein by inhibiting its ubiquitination and concomitant ubiquitin-mediated proteasomal degradation. Parkin does not stabilize the proteins of pathogenic PINK1 mutants (H271Q, G309D, E417G) due to the loss of their binding activities wisth Parkin.
Formal Description
Interaction-ID: 9366

gene/protein

PARK2

NOT increases_quantity of

gene/protein mutant

PINK1-p.E417G

by inhibiting its ubiquitin-mediated proteasomal degradation
Comment Parkin stabilizes PINK1 protein by inhibiting its ubiquitination and concomitant ubiquitin-mediated proteasomal degradation. Parkin does not stabilize the proteins of pathogenic PINK1 mutants (H271Q, G309D, E417G) due to the loss of their binding activities wisth Parkin.
Formal Description
Interaction-ID: 9367