General Information:

Id: 1,467 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
BTO:0000599 Hep-G2 cell
Reference: Kim JH et al.(2008) Regulation of interleukin-6-induced hepatic insulin resistance by mammalian target of rapamycin through the STAT3-SOCS3 pathway J. Biol. Chem. 283: 708-715 [PMID: 17993646]

Interaction Information:

Comment IL-6-induced SOCS3 expression is inhibited by rapamycin, and ectopic expression of SOCS3 blocks the ability of rapamycin to enhance insulin sensitivity in the presence of IL-6. SOCS3 mediates the role of mTOR in the IL-6 inhibition of insulin signaling.
Formal Description
Interaction-ID: 10449



decreases_activity of

in liver