General Information:

Id: 1,467 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
BTO:0000599 Hep-G2 cell
Reference: Kim JH et al.(2008) Regulation of interleukin-6-induced hepatic insulin resistance by mammalian target of rapamycin through the STAT3-SOCS3 pathway J. Biol. Chem. 283: 708-715 [PMID: 17993646]

Interaction Information:

Comment IL-6 activates S6K1 in HepG2 hepatocarcinoma cells, but unexpectedly, S6K1 is not involved in IL-6 inhibition of insulin signaling, since the effect of IL-6 persists in cells with drastically reduced S6K1 levels induced by RNA interference, suggesting that the function of mTOR signaling is through a mechanism different from the prevailing model of S6K1 phosphorylation of insulin receptor substrate-1.
Formal Description
Interaction-ID: 10441



NOT affects_activity of

in liver