General Information:

Id: 1,467 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
BTO:0000599 Hep-G2 cell
article
Reference: Kim JH et al.(2008) Regulation of interleukin-6-induced hepatic insulin resistance by mammalian target of rapamycin through the STAT3-SOCS3 pathway J. Biol. Chem. 283: 708-715 [PMID: 17993646]

Interaction Information:

Comment Pre-treatment of serum-starved HepG2 cells (a frequently untilized in vitro system for studying insulin's effects on hepatic cells) by IL-6 significantly dampened their response to acute insulin stimulation, as measured by Akt phosphorylation at Ser473.
Formal Description
Interaction-ID: 10356

gene/protein

IL6

decreases_activity of

in liver
Drugbank entries Show/Hide entries for IL6