General Information:

Id: 1,455
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
male
article
Reference: Wu D et al.(2007) Aging up-regulates expression of inflammatory mediators in mouse adipose tissue J. Immunol. 179: 4829-4839 [PMID: 17878382]

Interaction Information:

Comment Epididymal adipose tissue from old lean mice have higher mRNA expression of IL-1beta, IL-6, TNF-alpha, and COX-2 and lower mRNA expression of PPAR-gamma, a nuclear receptor possessing antiinflammatory and insulin-sensitizing properties, compared with those from young lean mice.
Formal Description
Interaction-ID: 10266

process

aging

increases_expression of

gene/protein

IL1B

in epididymal adipose tissue
Drugbank entries Show/Hide entries for IL1B
Comment Epididymal adipose tissue from old lean mice have higher mRNA expression of IL-1beta, IL-6, TNF-alpha, and COX-2 and lower mRNA expression of PPAR-gamma, a nuclear receptor possessing antiinflammatory and insulin-sensitizing properties, compared with those from young lean mice.
Formal Description
Interaction-ID: 10267

process

aging

increases_expression of

gene/protein

IL6

in epididymal adipose tissue
Drugbank entries Show/Hide entries for IL6
Comment Epididymal adipose tissue from old lean mice have higher mRNA expression of IL-1beta, IL-6, TNF-alpha, and COX-2 and lower mRNA expression of PPAR-gamma, a nuclear receptor possessing antiinflammatory and insulin-sensitizing properties, compared with those from young lean mice.
Formal Description
Interaction-ID: 10268

process

aging

increases_expression of

gene/protein

TNF

in epididymal adipose tissue
Drugbank entries Show/Hide entries for TNF
Comment Epididymal adipose tissue from old lean mice have higher mRNA expression of IL-1beta, IL-6, TNF-alpha, and COX-2 and lower mRNA expression of PPAR-gamma, a nuclear receptor possessing antiinflammatory and insulin-sensitizing properties, compared with those from young lean mice.
Formal Description
Interaction-ID: 10269

process

aging

increases_expression of

gene/protein

PTGS2

in epididymal adipose tissue
Drugbank entries Show/Hide entries for PTGS2
Comment Epididymal adipose tissue from old lean mice have higher mRNA expression of IL-1beta, IL-6, TNF-alpha, and COX-2 and lower mRNA expression of PPAR-gamma, a nuclear receptor possessing antiinflammatory and insulin-sensitizing properties, compared with those from young lean mice.
Formal Description
Interaction-ID: 10270

process

aging

decreases_expression of

gene/protein

PPARG

in epididymal adipose tissue
Drugbank entries Show/Hide entries for PPARG
Comment The number of macrophages in adipose tissue is not different between young and old mice.
Formal Description
Interaction-ID: 10271

process

aging

NOT affects_quantity of

tissue/cell line

macrophage

in adipose tissue
Comment Adipocytes and not stromal vascular cells including macrophages were the cells responsible for this higher inflammatory state of the aged adipose tissue, suggesting that the age-associated increase in adipose tissue inflammation is distinguished from that seen in obesity, in which macrophages are the main contributors.
Formal Description
Interaction-ID: 10272

tissue/cell line

adipocyte

increases_activity of

in aged adipose tissue
Comment Sphingolipid ceramide was higher in old compared with young adipose tissue.
Formal Description
Interaction-ID: 10274

process

aging

increases_quantity of

drug/chemical compound

Ceramide

in adipose tissue
Comment Ceramide-induced IL-6 and TNF-alpha production is mediated through NF-kappaB.
Formal Description
Interaction-ID: 10277

drug/chemical compound

Ceramide

increases_activity of

complex/PPI

NF-kappaB complex

in adipose tissue
Comment Ceramide-induced IL-6 and TNF-alpha production is mediated through NF-kappaB.
Formal Description
Interaction-ID: 10278

complex/PPI

NF-kappaB complex

increases_expression of

gene/protein

IL6

in adipose tissue
Drugbank entries Show/Hide entries for IL6
Comment Ceramide-induced IL-6 and TNF-alpha production is mediated through NF-kappaB.
Formal Description
Interaction-ID: 10279

complex/PPI

NF-kappaB complex

increases_expression of

gene/protein

TNF

in adipose tissue
Drugbank entries Show/Hide entries for TNF
Comment Aging up-regulates expression of inflammatory mediators in mouse adipose tissue.
Formal Description
Interaction-ID: 10280

process

aging

increases_activity of

in adipose tissue