CIDeRGeneral Information:
| Id: | 1,455 |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Mus musculus | |
| male | |
| article | |
| Reference: | Wu D et al.(2007) Aging up-regulates expression of inflammatory mediators in mouse adipose tissue J. Immunol. 179: 4829-4839 [PMID: 17878382] |
Interaction Information:
| Comment | Epididymal adipose tissue from old lean mice have higher mRNA expression of IL-1beta, IL-6, TNF-alpha, and COX-2 and lower mRNA expression of PPAR-gamma, a nuclear receptor possessing antiinflammatory and insulin-sensitizing properties, compared with those from young lean mice. |
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Formal Description Interaction-ID: 10266 |
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| Drugbank entries | Show/Hide entries for IL1B |
| Comment | Epididymal adipose tissue from old lean mice have higher mRNA expression of IL-1beta, IL-6, TNF-alpha, and COX-2 and lower mRNA expression of PPAR-gamma, a nuclear receptor possessing antiinflammatory and insulin-sensitizing properties, compared with those from young lean mice. |
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Formal Description Interaction-ID: 10267 |
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| Drugbank entries | Show/Hide entries for IL6 |
| Comment | Epididymal adipose tissue from old lean mice have higher mRNA expression of IL-1beta, IL-6, TNF-alpha, and COX-2 and lower mRNA expression of PPAR-gamma, a nuclear receptor possessing antiinflammatory and insulin-sensitizing properties, compared with those from young lean mice. |
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Formal Description Interaction-ID: 10268 |
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| Drugbank entries | Show/Hide entries for TNF |
| Comment | Epididymal adipose tissue from old lean mice have higher mRNA expression of IL-1beta, IL-6, TNF-alpha, and COX-2 and lower mRNA expression of PPAR-gamma, a nuclear receptor possessing antiinflammatory and insulin-sensitizing properties, compared with those from young lean mice. |
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Formal Description Interaction-ID: 10269 |
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| Drugbank entries | Show/Hide entries for PTGS2 |
| Comment | Epididymal adipose tissue from old lean mice have higher mRNA expression of IL-1beta, IL-6, TNF-alpha, and COX-2 and lower mRNA expression of PPAR-gamma, a nuclear receptor possessing antiinflammatory and insulin-sensitizing properties, compared with those from young lean mice. |
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Formal Description Interaction-ID: 10270 |
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| Drugbank entries | Show/Hide entries for PPARG |
| Comment | The number of macrophages in adipose tissue is not different between young and old mice. |
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Formal Description Interaction-ID: 10271 |
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| Comment | Adipocytes and not stromal vascular cells including macrophages were the cells responsible for this higher inflammatory state of the aged adipose tissue, suggesting that the age-associated increase in adipose tissue inflammation is distinguished from that seen in obesity, in which macrophages are the main contributors. |
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Formal Description Interaction-ID: 10272 |
tissue/cell line increases_activity of process |
| Comment | Sphingolipid ceramide was higher in old compared with young adipose tissue. |
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Formal Description Interaction-ID: 10274 |
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| Comment | Ceramide-induced IL-6 and TNF-alpha production is mediated through NF-kappaB. |
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Formal Description Interaction-ID: 10277 |
drug/chemical compound Ceramide increases_activity of complex/PPI NF-kappaB complex |
| Comment | Ceramide-induced IL-6 and TNF-alpha production is mediated through NF-kappaB. |
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Formal Description Interaction-ID: 10278 |
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| Drugbank entries | Show/Hide entries for IL6 |
| Comment | Ceramide-induced IL-6 and TNF-alpha production is mediated through NF-kappaB. |
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Formal Description Interaction-ID: 10279 |
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| Drugbank entries | Show/Hide entries for TNF |
| Comment | Aging up-regulates expression of inflammatory mediators in mouse adipose tissue. |
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Formal Description Interaction-ID: 10280 |
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