General Information:

Id: 1,454 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
BTO:0000011 3T3-L1 cell
article
Reference: Miller RS et al.(2007) Repression of GLUT4 expression by the endoplasmic reticulum stress response in 3T3-L1 adipocytes Biochem. Biophys. Res. Commun. 362: 188-192 [PMID: 17698029]

Interaction Information:

Comment Activation of the ER stress response increased the expression of CHOP10, an inhibitor of the activity and expression of C/EBPalpha.
Formal Description
Interaction-ID: 10261

increases_expression of

gene/protein

DDIT3

in adipose tissue
Comment Activation of the ER stress response decreased expression of C/EBPalpha, an activator of GLUT4 expression, providing a mechanism to account for the repression of GLUT4 by ER stress activation.
Formal Description
Interaction-ID: 10263

decreases_expression of

gene/protein

CEBPA

in adipose tissue
Comment Activation of the ER stress response decreased GLUT4 expression at the level of gene transcription.
Formal Description
Interaction-ID: 10265

decreases_expression of

gene/protein

SLC2A4

in adipose tissue