General Information:

Id: 1,453 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Mus musculus
male
article
Reference: Kiefer FW et al.(2010) Neutralization of osteopontin inhibits obesity-induced inflammation and insulin resistance Diabetes 59: 935-946 [PMID: 20107108]

Interaction Information:

Comment Insulin signaling in the liver leads to suppression of gluconeogenesis. The key gluconeogenic enzymes phosphoenolpyruvate carboxykinase (PEPCK; gene Pck1) and glucose 6 phosphatase (G6P; gene G6pc) that are targets of GSK-3beta and relevant markers of hepatic insulin resistance, were both significantly downregulated upon anti-osteopontin treatment.
Formal Description
Interaction-ID: 10259

gene/protein

SPP1

affects_activity of

process

gluconeogenesis

in liver