General Information:

Id: 1,450 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
male
article
Reference: Franckhauser S et al.(2008) Overexpression of Il6 leads to hyperinsulinaemia, liver inflammation and reduced body weight in mice Diabetologia 51: 1306-1316 [PMID: 18437347]

Interaction Information:

Comment In mice overexpressing IL-6 in skeletal muscle circulating lactate and triacylglycerol concentrations were decreased, as was leptin.
Formal Description
Interaction-ID: 10211

gene/protein

IL6

decreases_quantity of

gene/protein

LEP

in blood; if IL6 is overexpressed in skeletal muscle
Drugbank entries Show/Hide entries for IL6
Comment In mice overexpressing IL-6 in skeletal muscle there were no significant changes in the adipose tissue, barring leptin, where a significant reduction was seen.
Formal Description
Interaction-ID: 10230

gene/protein

IL6

decreases_expression of

gene/protein

LEP

in adipose tissue; if IL6 is overexpressed in skeletal muscle
Drugbank entries Show/Hide entries for IL6