General Information:

Id: 1,450 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
male
article
Reference: Franckhauser S et al.(2008) Overexpression of Il6 leads to hyperinsulinaemia, liver inflammation and reduced body weight in mice Diabetologia 51: 1306-1316 [PMID: 18437347]

Interaction Information:

Comment In mice overexpressing IL-6 in skeletal muscle the adiponectin receptors 1 and 2 were significantly decreased while Ucp2 was increased in skeletal muscle. Several mitochondrial genes (cytochrome C, Cox2 [also known as mt-Co2], beta-ATP synthase and mt-Tfa [also known as Tfam]) were decreased, and PGC1alpha (also known as Ppargc1a) was also significantly deceased in skeletal muscle.
Formal Description
Interaction-ID: 10229

gene/protein

IL6

decreases_expression of

gene/protein

PPARGC1A

in skeletal muscle; if IL6 is overexpressed in skeletal muscle
Drugbank entries Show/Hide entries for IL6
Comment In mice overexpressing IL-6 in skeletal muscle the mRNA levels of Pepck and fatty acid synthase were markedly decreased in the liver. Furthermore, Il6 and Socs3 were increased together with several markers of inflammation, including Saa, Tnf-alpha (also known as Tnf) and Mcp-1 (also known as Ccl2). PGC1alpha and adiponectin receptor 2 were also significantly decreased.
Formal Description
Interaction-ID: 10237

gene/protein

IL6

decreases_expression of

gene/protein

PPARGC1A

in liver; if IL6 is overexpressed in skeletal muscle
Drugbank entries Show/Hide entries for IL6