General Information:

Id: 1,450
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
male
article
Reference: Franckhauser S et al.(2008) Overexpression of Il6 leads to hyperinsulinaemia, liver inflammation and reduced body weight in mice Diabetologia 51: 1306-1316 [PMID: 18437347]

Interaction Information:

Comment IL-6 overproduction in skeletal muscle leads to body weight loss and decreased fat mass, but food intake is unchanged, which is consistent with the finding that IL-6 increased energy expenditure.
Formal Description
Interaction-ID: 10184

gene/protein

IL6

decreases_quantity of

tissue/cell line

adipose tissue

if IL6 is overexpressed in skeletal muscle
Drugbank entries Show/Hide entries for IL6
Comment IL-6 overproduction in skeletal muscle leads to body weight loss and decreased fat mass, but food intake is unchanged, which is consistent with the finding that IL-6 increased energy expenditure.
Formal Description
Interaction-ID: 10201

gene/protein

IL6

increases_activity of

if IL6 is overexpressed in skeletal muscle
Drugbank entries Show/Hide entries for IL6
Comment Skeletal muscle IL-6 overabundance is associated with hypoglycaemia and inappropriate hyperinsulinaemia.
Formal Description
Interaction-ID: 10202

gene/protein

IL6

increases_activity of

phenotype

hypoglycemia

if IL6 is overexpressed in skeletal muscle
Drugbank entries Show/Hide entries for IL6
Comment Skeletal muscle IL-6 overabundance is associated with hypoglycaemia and inappropriate hyperinsulinaemia.
Formal Description
Interaction-ID: 10203

gene/protein

IL6

increases_activity of

if IL6 is overexpressed in skeletal muscle
Drugbank entries Show/Hide entries for IL6
Comment Both serum NEFA and glycerol levels were greatly decreased in mice overexpressing IL-6 in skeletal muscle.
Formal Description
Interaction-ID: 10204

gene/protein

IL6

decreases_quantity of

drug/chemical compound

Fatty acid

in blood; if IL6 is overexpressed in skeletal muscle
Drugbank entries Show/Hide entries for IL6
Comment Both serum NEFA and glycerol levels were greatly decreased in mice overexpressing IL-6 in skeletal muscle.
Formal Description
Interaction-ID: 10206

gene/protein

IL6

decreases_quantity of

drug/chemical compound

Glycerol

in blood; if IL6 is overexpressed in skeletal muscle
Drugbank entries Show/Hide entries for IL6 or Glycerol
Comment In mice overexpressing IL-6 in skeletal muscle circulating lactate and triacylglycerol concentrations were decreased, as was leptin.
Formal Description
Interaction-ID: 10209

gene/protein

IL6

decreases_quantity of

drug/chemical compound

Lactate

in blood; if IL6 is overexpressed in skeletal muscle
Drugbank entries Show/Hide entries for IL6
Comment In mice overexpressing IL-6 in skeletal muscle circulating lactate and triacylglycerol concentrations were decreased, as was leptin.
Formal Description
Interaction-ID: 10210

gene/protein

IL6

decreases_quantity of

drug/chemical compound

Triacylglycerol

in blood; if IL6 is overexpressed in skeletal muscle
Drugbank entries Show/Hide entries for IL6
Comment In mice overexpressing IL-6 in skeletal muscle circulating lactate and triacylglycerol concentrations were decreased, as was leptin.
Formal Description
Interaction-ID: 10211

gene/protein

IL6

decreases_quantity of

gene/protein

LEP

in blood; if IL6 is overexpressed in skeletal muscle
Drugbank entries Show/Hide entries for IL6
Comment In mice overexpressing IL-6 in skeletal muscle adiponectin levels were also greatly reduced, in contrast to what would be expected in view of the reduced adipose mass and small fat cell size.
Formal Description
Interaction-ID: 10212

gene/protein

IL6

decreases_quantity of

gene/protein

ADIPOQ

in blood; if IL6 is overexpressed in skeletal muscle
Drugbank entries Show/Hide entries for IL6
Comment High levels of circulating IL-6 lead to decreased skeletal muscle glucose uptake and GLUT-4 content.
Formal Description
Interaction-ID: 10213

gene/protein

IL6

decreases_activity of

process

glucose import

into skeletal muscle; if IL6 is overexpressed in skeletal muscle
Drugbank entries Show/Hide entries for IL6
Comment High levels of circulating IL-6 lead to decreased skeletal muscle glucose uptake and GLUT-4 content.
Formal Description
Interaction-ID: 10214

gene/protein

IL6

decreases_quantity of

gene/protein

SLC2A4

in skeletal muscle; if IL6 is overexpressed in skeletal muscle
Drugbank entries Show/Hide entries for IL6
Comment IL-6 overexpression in skeletal muscle increases the phosphorylation of AMPK.
Formal Description
Interaction-ID: 10215

gene/protein

IL6

increases_phosphorylation of

complex/PPI

AMPK

if IL6 is overexpressed in skeletal muscle
Drugbank entries Show/Hide entries for IL6
Comment Overproduction of IL-6 leads to systemic inflammation and decreased glucose production.
Formal Description
Interaction-ID: 10216

gene/protein

IL6

increases_activity of

if IL6 is overexpressed in skeletal muscle
Drugbank entries Show/Hide entries for IL6
Comment Overproduction of IL-6 leads to systemic inflammation and decreased glucose production.
Formal Description
Interaction-ID: 10217

gene/protein

IL6

decreases_activity of

process

gluconeogenesis

if IL6 is overexpressed in skeletal muscle
Drugbank entries Show/Hide entries for IL6
Comment In mice overexpressing IL-6 in skeletal muscle, liver Pepck (also known as Pck1) mRNA levels are markedly reduced.
Formal Description
Interaction-ID: 10218

gene/protein

IL6

decreases_expression of

gene/protein

PCK1

in liver; if IL6 is overexpressed in skeletal muscle
Drugbank entries Show/Hide entries for IL6 or PCK1
Comment In mice overexpressing IL-6 in skeletal muscle there was a marked increase in Il6 receptor as well as in Socs3 mRNA levels in the skeletal muscle, while Socs1 was unchanged.
Formal Description
Interaction-ID: 10219

gene/protein

IL6

increases_expression of

gene/protein

IL6R

in skeletal muscle; if IL6 is overexpressed in skeletal muscle
Drugbank entries Show/Hide entries for IL6 or IL6R
Comment In mice overexpressing IL-6 in skeletal muscle there was a marked increase in Il6 receptor as well as in Socs3 mRNA levels in the skeletal muscle, while Socs1 was unchanged.
Formal Description
Interaction-ID: 10220

gene/protein

IL6

increases_expression of

gene/protein

SOCS3

in skeletal muscle; if IL6 is overexpressed in skeletal muscle
Drugbank entries Show/Hide entries for IL6
Comment In mice overexpressing IL-6 in skeletal muscle there was a marked increase in Il6 receptor as well as in Socs3 mRNA levels in the skeletal muscle, while Socs1 was unchanged.
Formal Description
Interaction-ID: 10221

gene/protein

IL6

NOT affects_expression of

gene/protein

SOCS1

in skeletal muscle; if IL6 is overexpressed in skeletal muscle
Drugbank entries Show/Hide entries for IL6
Comment In mice overexpressing IL-6 in skeletal muscle the adiponectin receptors 1 and 2 were significantly decreased while Ucp2 was increased in skeletal muscle. Several mitochondrial genes (cytochrome C, Cox2 [also known as mt-Co2], beta-ATP synthase and mt-Tfa [also known as Tfam]) were decreased, and PGC1alpha (also known as Ppargc1a) was also significantly deceased in skeletal muscle.
Formal Description
Interaction-ID: 10222

gene/protein

IL6

decreases_expression of

gene/protein

ADIPOR1

in skeletal muscle; if IL6 is overexpressed in skeletal muscle
Drugbank entries Show/Hide entries for IL6
Comment In mice overexpressing IL-6 in skeletal muscle the adiponectin receptors 1 and 2 were significantly decreased while Ucp2 was increased in skeletal muscle. Several mitochondrial genes (cytochrome C, Cox2 [also known as mt-Co2], beta-ATP synthase and mt-Tfa [also known as Tfam]) were decreased, and PGC1alpha (also known as Ppargc1a) was also significantly deceased in skeletal muscle.
Formal Description
Interaction-ID: 10223

gene/protein

IL6

decreases_expression of

gene/protein

ADIPOR2

in skeletal muscle; if IL6 is overexpressed in skeletal muscle
Drugbank entries Show/Hide entries for IL6
Comment In mice overexpressing IL-6 in skeletal muscle the adiponectin receptors 1 and 2 were significantly decreased while Ucp2 was increased in skeletal muscle. Several mitochondrial genes (cytochrome C, Cox2 [also known as mt-Co2], beta-ATP synthase and mt-Tfa [also known as Tfam]) were decreased, and PGC1alpha (also known as Ppargc1a) was also significantly deceased in skeletal muscle.
Formal Description
Interaction-ID: 10224

gene/protein

IL6

increases_expression of

gene/protein

UCP2

in skeletal muscle; if IL6 is overexpressed in skeletal muscle
Drugbank entries Show/Hide entries for IL6
Comment In mice overexpressing IL-6 in skeletal muscle the adiponectin receptors 1 and 2 were significantly decreased while Ucp2 was increased in skeletal muscle. Several mitochondrial genes (cytochrome C, Cox2 [also known as mt-Co2], beta-ATP synthase and mt-Tfa [also known as Tfam]) were decreased, and PGC1alpha (also known as Ppargc1a) was also significantly deceased in skeletal muscle.
Formal Description
Interaction-ID: 10225

gene/protein

IL6

decreases_expression of

gene/protein

CYCS

in skeletal muscle; if IL6 is overexpressed in skeletal muscle
Drugbank entries Show/Hide entries for IL6 or CYCS
Comment In mice overexpressing IL-6 in skeletal muscle the adiponectin receptors 1 and 2 were significantly decreased while Ucp2 was increased in skeletal muscle. Several mitochondrial genes (cytochrome C, Cox2 [also known as mt-Co2], beta-ATP synthase and mt-Tfa [also known as Tfam]) were decreased, and PGC1alpha (also known as Ppargc1a) was also significantly deceased in skeletal muscle.
Formal Description
Interaction-ID: 10226

gene/protein

IL6

decreases_expression of

gene/protein

MT-CO2

in skeletal muscle; if IL6 is overexpressed in skeletal muscle
Drugbank entries Show/Hide entries for IL6 or MT-CO2
Comment In mice overexpressing IL-6 in skeletal muscle the adiponectin receptors 1 and 2 were significantly decreased while Ucp2 was increased in skeletal muscle. Several mitochondrial genes (cytochrome C, Cox2 [also known as mt-Co2], beta-ATP synthase and mt-Tfa [also known as Tfam]) were decreased, and PGC1alpha (also known as Ppargc1a) was also significantly deceased in skeletal muscle.
Formal Description
Interaction-ID: 10227

gene/protein

IL6

decreases_expression of

gene/protein

ATP5B

in skeletal muscle; if IL6 is overexpressed in skeletal muscle
Drugbank entries Show/Hide entries for IL6 or ATP5B
Comment In mice overexpressing IL-6 in skeletal muscle the adiponectin receptors 1 and 2 were significantly decreased while Ucp2 was increased in skeletal muscle. Several mitochondrial genes (cytochrome C, Cox2 [also known as mt-Co2], beta-ATP synthase and mt-Tfa [also known as Tfam]) were decreased, and PGC1alpha (also known as Ppargc1a) was also significantly deceased in skeletal muscle.
Formal Description
Interaction-ID: 10228

gene/protein

IL6

decreases_expression of

gene/protein

TFAM

in skeletal muscle; if IL6 is overexpressed in skeletal muscle
Drugbank entries Show/Hide entries for IL6
Comment In mice overexpressing IL-6 in skeletal muscle the adiponectin receptors 1 and 2 were significantly decreased while Ucp2 was increased in skeletal muscle. Several mitochondrial genes (cytochrome C, Cox2 [also known as mt-Co2], beta-ATP synthase and mt-Tfa [also known as Tfam]) were decreased, and PGC1alpha (also known as Ppargc1a) was also significantly deceased in skeletal muscle.
Formal Description
Interaction-ID: 10229

gene/protein

IL6

decreases_expression of

gene/protein

PPARGC1A

in skeletal muscle; if IL6 is overexpressed in skeletal muscle
Drugbank entries Show/Hide entries for IL6
Comment In mice overexpressing IL-6 in skeletal muscle there were no significant changes in the adipose tissue, barring leptin, where a significant reduction was seen.
Formal Description
Interaction-ID: 10230

gene/protein

IL6

decreases_expression of

gene/protein

LEP

in adipose tissue; if IL6 is overexpressed in skeletal muscle
Drugbank entries Show/Hide entries for IL6
Comment In mice overexpressing IL-6 in skeletal muscle the mRNA levels of Pepck and fatty acid synthase were markedly decreased in the liver. Furthermore, Il6 and Socs3 were increased together with several markers of inflammation, including Saa, Tnf-alpha (also known as Tnf) and Mcp-1 (also known as Ccl2). PGC1alpha and adiponectin receptor 2 were also significantly decreased.
Formal Description
Interaction-ID: 10231

gene/protein

IL6

decreases_expression of

gene/protein

FASN

in liver; if IL6 is overexpressed in skeletal muscle
Drugbank entries Show/Hide entries for IL6 or FASN
Comment In mice overexpressing IL-6 in skeletal muscle the mRNA levels of Pepck and fatty acid synthase were markedly decreased in the liver. Furthermore, Il6 and Socs3 were increased together with several markers of inflammation, including Saa, Tnf-alpha (also known as Tnf) and Mcp-1 (also known as Ccl2). PGC1alpha and adiponectin receptor 2 were also significantly decreased.
Formal Description
Interaction-ID: 10232

gene/protein

IL6

increases_expression of

gene/protein

IL6

in liver; if IL6 is overexpressed in skeletal muscle
Drugbank entries Show/Hide entries for IL6 or IL6
Comment In mice overexpressing IL-6 in skeletal muscle the mRNA levels of Pepck and fatty acid synthase were markedly decreased in the liver. Furthermore, Il6 and Socs3 were increased together with several markers of inflammation, including Saa, Tnf-alpha (also known as Tnf) and Mcp-1 (also known as Ccl2). PGC1alpha and adiponectin receptor 2 were also significantly decreased.
Formal Description
Interaction-ID: 10233

gene/protein

IL6

increases_expression of

gene/protein

SOCS3

in liver; if IL6 is overexpressed in skeletal muscle
Drugbank entries Show/Hide entries for IL6
Comment In mice overexpressing IL-6 in skeletal muscle the mRNA levels of Pepck and fatty acid synthase were markedly decreased in the liver. Furthermore, Il6 and Socs3 were increased together with several markers of inflammation, including Saa, Tnf-alpha (also known as Tnf) and Mcp-1 (also known as Ccl2). PGC1alpha and adiponectin receptor 2 were also significantly decreased.
Formal Description
Interaction-ID: 10234

gene/protein

IL6

increases_expression of

gene/protein

SAA2

in liver; if IL6 is overexpressed in skeletal muscle
Drugbank entries Show/Hide entries for IL6
Comment In mice overexpressing IL-6 in skeletal muscle the mRNA levels of Pepck and fatty acid synthase were markedly decreased in the liver. Furthermore, Il6 and Socs3 were increased together with several markers of inflammation, including Saa, Tnf-alpha (also known as Tnf) and Mcp-1 (also known as Ccl2). PGC1alpha and adiponectin receptor 2 were also significantly decreased.
Formal Description
Interaction-ID: 10235

gene/protein

IL6

increases_expression of

gene/protein

TNF

in liver; if IL6 is overexpressed in skeletal muscle
Drugbank entries Show/Hide entries for IL6 or TNF
Comment In mice overexpressing IL-6 in skeletal muscle the mRNA levels of Pepck and fatty acid synthase were markedly decreased in the liver. Furthermore, Il6 and Socs3 were increased together with several markers of inflammation, including Saa, Tnf-alpha (also known as Tnf) and Mcp-1 (also known as Ccl2). PGC1alpha and adiponectin receptor 2 were also significantly decreased.
Formal Description
Interaction-ID: 10236

gene/protein

IL6

increases_expression of

gene/protein

CCL2

in liver; if IL6 is overexpressed in skeletal muscle
Drugbank entries Show/Hide entries for IL6 or CCL2
Comment In mice overexpressing IL-6 in skeletal muscle the mRNA levels of Pepck and fatty acid synthase were markedly decreased in the liver. Furthermore, Il6 and Socs3 were increased together with several markers of inflammation, including Saa, Tnf-alpha (also known as Tnf) and Mcp-1 (also known as Ccl2). PGC1alpha and adiponectin receptor 2 were also significantly decreased.
Formal Description
Interaction-ID: 10237

gene/protein

IL6

decreases_expression of

gene/protein

PPARGC1A

in liver; if IL6 is overexpressed in skeletal muscle
Drugbank entries Show/Hide entries for IL6
Comment In mice overexpressing IL-6 in skeletal muscle the mRNA levels of Pepck and fatty acid synthase were markedly decreased in the liver. Furthermore, Il6 and Socs3 were increased together with several markers of inflammation, including Saa, Tnf-alpha (also known as Tnf) and Mcp-1 (also known as Ccl2). PGC1alpha and adiponectin receptor 2 were also significantly decreased.
Formal Description
Interaction-ID: 10238

gene/protein

IL6

decreases_expression of

gene/protein

ADIPOR2

in liver; if IL6 is overexpressed in skeletal muscle
Drugbank entries Show/Hide entries for IL6