General Information:

Id: 1,449 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mammalia
BTO:0000793 SH-SY5Y cell; BTO:0004488 NSC-34 cell
article
Reference: Ferri A et al.(2010) Glutaredoxin 2 prevents aggregation of mutant SOD1 in mitochondria and abolishes its toxicity Hum. Mol. Genet. 19: 4529-4542 [PMID: 20829229]

Interaction Information:

Comment Overexpression of Grx1 increases the solubility of mutant SOD1 G93A in the cytosol but does not inhibit mitochondrial damage and apoptosis induced by mutant SOD1 in neuronal cells (SH-SY5Y) or in immortalized motoneurons (NSC-34).
Formal Description
Interaction-ID: 10208

gene/protein mutant

SOD1-p.G93A

increases_activity of

in mitochondria