General Information:

Id: 1,449 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mammalia
BTO:0000793 SH-SY5Y cell; BTO:0004488 NSC-34 cell
article
Reference: Ferri A et al.(2010) Glutaredoxin 2 prevents aggregation of mutant SOD1 in mitochondria and abolishes its toxicity Hum. Mol. Genet. 19: 4529-4542 [PMID: 20829229]

Interaction Information:

Comment Overexpression of Grx2 increases the solubility of mutant SOD1 in mitochondria, interferes with mitochondrial fragmentation by modifying the expression pattern of proteins involved in mitochondrial dynamics, preserves mitochondrial function and strongly protects neuronal cells from apoptosis.
Formal Description
Interaction-ID: 10189

gene/protein

GLRX2

decreases_activity of

in mitochondria of mutant SOD1G93A transfected cell lines; if GRX2 is overexpressed
Drugbank entries Show/Hide entries for GLRX2
Comment Overexpression of Grx1 increases the solubility of mutant SOD1 G93A in the cytosol but does not inhibit mitochondrial damage and apoptosis induced by mutant SOD1 in neuronal cells (SH-SY5Y) or in immortalized motoneurons (NSC-34).
Formal Description
Interaction-ID: 10208

gene/protein mutant

SOD1-p.G93A

increases_activity of

in mitochondria