General Information:

Id: 1,448 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
male
article
Reference: Weigert C et al.(2006) Direct cross-talk of interleukin-6 and insulin signal transduction via insulin receptor substrate-1 in skeletal muscle cells J. Biol. Chem. 281: 7060-7067 [PMID: 16418171]

Interaction Information:

Comment Two inhibitory mechanisms of IL-6 on insulin action, phosphorylation of the inhibitory Ser-307 residue of IRS-1 and induction of SOCS-3 expression, were only found in liver but not in muscle of IL-6-treated mice.
Formal Description
Interaction-ID: 10183

gene/protein

IL6

decreases_activity of

in liver
Drugbank entries Show/Hide entries for IL6