General Information:

Id: 1,441 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Hemochromatosis, type 1 - [OMIM]
Mammalia
review
Reference: Cahill CM et al.(2009) Amyloid precursor protein and alpha synuclein translation, implications for iron and inflammation in neurodegenerative diseases Biochim. Biophys. Acta 1790: 615-628 [PMID: 19166904]

Interaction Information:

Comment Iron enhances cleavage of the Abeta-peptide domain of APP by the metalloprotease alpha secretase.
Formal Description
Interaction-ID: 10384

drug/chemical compound

Iron

increases_activity of

gene/protein

Alpha-secretase