General Information:

Id: 1,441 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Hemochromatosis, type 1 - [OMIM]
Mammalia
review
Reference: Cahill CM et al.(2009) Amyloid precursor protein and alpha synuclein translation, implications for iron and inflammation in neurodegenerative diseases Biochim. Biophys. Acta 1790: 615-628 [PMID: 19166904]

Interaction Information:

Comment There are evidences of metal dependent translation of APP mRNA, the involvement of metals in the plaque of AD patients and of increased iron in striatal neurons in the substantia nigra (SN) of Parkinson's disease patients.
Formal Description
Interaction-ID: 10318

drug/chemical compound

Iron

affects_activity of

tissue/cell line

striatal neuron

in the substantia nigra (SN); of Parkinson's disease patients
Comment Brain autopsy samples from AD patients have elevated levels of ferritin iron, particularly in the neurons of the basal ganglia and most amyloid plaques contain iron and ferritin-rich cells.
Formal Description
Interaction-ID: 10350

drug/chemical compound

Iron

is localized in

tissue/cell line

basal ganglion

in AD patients
Comment Brain autopsy samples from AD patients have elevated levels of ferritin iron, particularly in the neurons of the basal ganglia and most amyloid plaques contain iron and ferritin-rich cells.
Formal Description
Interaction-ID: 10351

drug/chemical compound

Iron

is localized in

phenotype

ferritin-rich cell

in AD patients
Comment Iron enhances cleavage of the Abeta-peptide domain of APP by the metalloprotease alpha secretase.
Formal Description
Interaction-ID: 10384

drug/chemical compound

Iron

increases_activity of

gene/protein

Alpha-secretase