General Information:

Id: 1,441 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Hemochromatosis, type 1 - [OMIM]
Mammalia
review
Reference: Cahill CM et al.(2009) Amyloid precursor protein and alpha synuclein translation, implications for iron and inflammation in neurodegenerative diseases Biochim. Biophys. Acta 1790: 615-628 [PMID: 19166904]

Interaction Information:

Comment There are evidences of metal dependent translation of APP mRNA, the involvement of metals in the plaque of AD patients and of increased iron in striatal neurons in the substantia nigra (SN) of Parkinson's disease patients.
Formal Description
Interaction-ID: 10318

drug/chemical compound

Iron

affects_activity of

tissue/cell line

striatal neuron

in the substantia nigra (SN); of Parkinson's disease patients