General Information:

Id: 143 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
BTO:0004488 NSC-34 cell; BTO:0000312 motoneuron
Reference: Suzuki H et al.(2009) ALS-linked P56S-VAPB, an aggregated loss-of-function mutant of VAPB, predisposes motor neurons to ER stress-related death by inducing aggregation of co-expressed wild-type VAPB J. Neurochem. 108: 973-985 [PMID: 19183264]

Interaction Information:

Comment Wt-VAPB, but not P56S-VAPB, induces the activation of the unfolded protein response (UPR) IRE1/XBP1 pathway.
Formal Description
Interaction-ID: 513

gene/protein mutant


NOT affects_activity of