General Information:

Id: 1,439 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mus musculus
article
Reference: Netea MG et al.(2006) Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance Nat. Med. 12: 650-656 [PMID: 16732281]

Interaction Information:

Comment The expression of phosphoenolpyruvate carboxykinase (PEPCK-1, encoded by Pck1) in the livers of 6-month-old Il18-/- mice was substantially higher than that of control Il18+/+ mice. In contrast, the expression of peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha, encoded by Ppargc1a) did not differ between the two strains of mice.
Formal Description
Interaction-ID: 10132

gene/protein

IL18

NOT affects_expression of

gene/protein

PPARGC1A

in liver