General Information:

Id: 1,439
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mus musculus
article
Reference: Netea MG et al.(2006) Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance Nat. Med. 12: 650-656 [PMID: 16732281]

Interaction Information:

Comment IL-18 knockout mice have a markedly increased body weight compared to wild-type littermates of the same age.
Formal Description
Interaction-ID: 10097

gene/protein

IL18

affects_activity of

Comment IL-18 knockout mice have a markedly increased body weight compared to wild-type littermates of the same age.
Formal Description
Interaction-ID: 10098

gene/protein

IL18

affects_activity of

disease

Obesity

Comment When food intake and energy expenditure were analyzed by housing the mice in metabolic cages, Il18-/- mice ate significantly more than their control counterparts, although the metabolic rate did not differ between the strains.
Formal Description
Interaction-ID: 10099

gene/protein

IL18

affects_activity of

Comment When food intake and energy expenditure were analyzed by housing the mice in metabolic cages, Il18-/- mice ate significantly more than their control counterparts, although the metabolic rate did not differ between the strains.
Formal Description
Interaction-ID: 10101

gene/protein

IL18

NOT affects_activity of

Comment When food intake and energy expenditure were analyzed by housing the mice in metabolic cages, Il18-/- mice ate significantly more than their control counterparts, although the metabolic rate did not differ between the strains.
Formal Description
Interaction-ID: 10108

gene/protein

IL18

NOT affects_activity of

Comment Leptin concentrations were higher in the Il18-/- mice, and they were strongly correlated with body weight.
Formal Description
Interaction-ID: 10110

gene/protein

LEP

affects_activity of

Comment Leptin concentrations were higher in the Il18-/- mice, and they were strongly correlated with body weight.
Formal Description
Interaction-ID: 10111

gene/protein

IL18

affects_quantity of

gene/protein

LEP

Comment Il18-/- mice also had hyperinsulinemia, consistent with insulin resistance and hyperglycemia.
Formal Description
Interaction-ID: 10112

gene/protein

IL18

affects_activity of

Comment Il18-/- mice also had hyperinsulinemia, consistent with insulin resistance and hyperglycemia.
Formal Description
Interaction-ID: 10113

gene/protein

IL18

affects_activity of

disease

Insulin resistance

Comment Il18-/- mice also had hyperinsulinemia, consistent with insulin resistance and hyperglycemia.
Formal Description
Interaction-ID: 10114

gene/protein

IL18

affects_activity of

phenotype

hyperglycemia

Comment Il18-/- mice had increased cholesterol and triglyceride concentrations. The increased cholesterol concentration resulted largely from elevated high-density lipoprotein (HDL).
Formal Description
Interaction-ID: 10120

gene/protein

IL18

affects_quantity of

drug/chemical compound

Cholesterol

Drugbank entries Show/Hide entries for
Comment Il18-/- mice had increased cholesterol and triglyceride concentrations. The increased cholesterol concentration resulted largely from elevated high-density lipoprotein (HDL).
Formal Description
Interaction-ID: 10121

gene/protein

IL18

affects_quantity of

drug/chemical compound

Triacylglycerol

Comment Il18-/- mice have abnormal glucose and insulin tolerance.
Formal Description
Interaction-ID: 10124

gene/protein

IL18

affects_activity of

Comment Il18-/- mice have abnormal glucose and insulin tolerance.
Formal Description
Interaction-ID: 10125

gene/protein

IL18

affects_activity of

Comment IL18r1-/- mice are obese.
Formal Description
Interaction-ID: 10128

gene/protein

IL18R1

affects_activity of

disease

Obesity

Comment The expression of phosphoenolpyruvate carboxykinase (PEPCK-1, encoded by Pck1) in the livers of 6-month-old Il18-/- mice was substantially higher than that of control Il18+/+ mice. In contrast, the expression of peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha, encoded by Ppargc1a) did not differ between the two strains of mice.
Formal Description
Interaction-ID: 10131

gene/protein

IL18

affects_expression of

gene/protein

PCK1

in liver
Drugbank entries Show/Hide entries for PCK1
Comment The expression of phosphoenolpyruvate carboxykinase (PEPCK-1, encoded by Pck1) in the livers of 6-month-old Il18-/- mice was substantially higher than that of control Il18+/+ mice. In contrast, the expression of peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha, encoded by Ppargc1a) did not differ between the two strains of mice.
Formal Description
Interaction-ID: 10132

gene/protein

IL18

NOT affects_expression of

gene/protein

PPARGC1A

in liver
Comment Recombinant IL-18 (rIL-18) reversed hyperglycemia in Il18-/- mice through activation of STAT3 phosphorylation.
Formal Description
Interaction-ID: 10133

gene/protein

IL18

increases_phosphorylation of

gene/protein

STAT3

Comment Recombinant IL-18 (rIL-18) reversed hyperglycemia in Il18-/- mice through activation of STAT3 phosphorylation.
Formal Description
Interaction-ID: 10134

gene/protein

IL18

increases_activity of

gene/protein

STAT3