General Information:

Id: 1,435 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
article
Reference: Sauter NS et al.(2008) The antiinflammatory cytokine interleukin-1 receptor antagonist protects from high-fat diet-induced hyperglycemia Endocrinology 149: 2208-2218 [PMID: 18239070]

Interaction Information:

Comment Levels of the adipokines leptin and resistin were raised 22- and 1.8-fold in the vehicle-treated high-fat/high-sucrose diet (HFD) group compared with the normal diet (ND), respectively. IL-1Ra treatment led to a 3.9- and 1.6-fold reduction in leptin and resistin levels in the HFD group, respectively.
Formal Description
Interaction-ID: 10057

environment

high-fat high-sucrose diet

increases_quantity of

gene/protein

LEP