General Information:

Id: 1,435
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
article
Reference: Sauter NS et al.(2008) The antiinflammatory cytokine interleukin-1 receptor antagonist protects from high-fat diet-induced hyperglycemia Endocrinology 149: 2208-2218 [PMID: 18239070]

Interaction Information:

Comment IL-1Ra protects from diet-induced hyperglycemia and improves glucose tolerance in mice.
Formal Description
Interaction-ID: 10051

gene/protein

IL1RN

decreases_activity of

phenotype

hyperglycemia

if hyperglycemia is diet-induced
Comment IL-1Ra protects from diet-induced hyperglycemia and improves glucose tolerance in mice.
Formal Description
Interaction-ID: 10052

gene/protein

IL1RN

increases_activity of

Comment Islets from high-fat fed-mice that were treated with IL-1Ra showed a rate of beta-cell apoptosis similar to islets from the normal diet group.
Formal Description
Interaction-ID: 10056

gene/protein

IL1RN

decreases_activity of

after high-fat diet
Comment Levels of the adipokines leptin and resistin were raised 22- and 1.8-fold in the vehicle-treated high-fat/high-sucrose diet (HFD) group compared with the normal diet (ND), respectively. IL-1Ra treatment led to a 3.9- and 1.6-fold reduction in leptin and resistin levels in the HFD group, respectively.
Formal Description
Interaction-ID: 10057

environment

high-fat high-sucrose diet

increases_quantity of

gene/protein

LEP

Comment Levels of the adipokines leptin and resistin were raised 22- and 1.8-fold in the vehicle-treated high-fat/high-sucrose diet (HFD) group compared with the normal diet (ND), respectively. IL-1Ra treatment led to a 3.9- and 1.6-fold reduction in leptin and resistin levels in the HFD group, respectively.
Formal Description
Interaction-ID: 10088

environment

high-fat high-sucrose diet

increases_quantity of

gene/protein

RETN

Comment Levels of the adipokines leptin and resistin were raised 22- and 1.8-fold in the vehicle-treated high-fat/high-sucrose diet (HFD) group compared with the normal diet (ND), respectively. IL-1Ra treatment led to a 3.9- and 1.6-fold reduction in leptin and resistin levels in the HFD group, respectively.
Formal Description
Interaction-ID: 10089

gene/protein

IL1RN

decreases_quantity of

gene/protein

LEP

after high-fat high-sucrose diet
Comment Levels of the adipokines leptin and resistin were raised 22- and 1.8-fold in the vehicle-treated high-fat/high-sucrose diet (HFD) group compared with the normal diet (ND), respectively. IL-1Ra treatment led to a 3.9- and 1.6-fold reduction in leptin and resistin levels in the HFD group, respectively.
Formal Description
Interaction-ID: 10090

gene/protein

IL1RN

decreases_quantity of

gene/protein

RETN

after high-fat high-sucrose diet
Comment High-fat/high-sucrose diet (HFD) treatment increased serum levels of free fatty acids, which were reduced by IL-1Ra treatment.
Formal Description
Interaction-ID: 10091

environment

high-fat high-sucrose diet

increases_quantity of

drug/chemical compound

Fatty acid

in blood
Comment High-fat/high-sucrose diet (HFD) treatment increased serum levels of free fatty acids, which were reduced by IL-1Ra treatment.
Formal Description
Interaction-ID: 10092

gene/protein

IL1RN

decreases_quantity of

drug/chemical compound

Fatty acid

in blood; after high-fat high-sucrose diet
Comment IL-1Ra counteracted adiponectin levels, which were decreased by high-fat feeding.
Formal Description
Interaction-ID: 10093

environment

high-fat high-sucrose diet

decreases_quantity of

gene/protein

ADIPOQ

Comment IL-1Ra counteracted adiponectin levels, which were decreased by high-fat feeding.
Formal Description
Interaction-ID: 10094

gene/protein

IL1RN

increases_quantity of

gene/protein

ADIPOQ

after high-fat high-sucrose diet
Comment Insulin mRNA was reduced in islets from mice fed a high-fat/high-sucrose diet (HFD) but normalized in the IL-1Ra group.
Formal Description
Interaction-ID: 10095

environment

high-fat high-sucrose diet

decreases_expression of

gene/protein

INS

Drugbank entries Show/Hide entries for INS
Comment Insulin mRNA was reduced in islets from mice fed a high-fat/high-sucrose diet (HFD) but normalized in the IL-1Ra group.
Formal Description
Interaction-ID: 10096

gene/protein

IL1RN

increases_expression of

gene/protein

INS

after high-fat high-sucrose diet
Drugbank entries Show/Hide entries for INS