General Information:

Id: 1,429 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Homo sapiens
BTO:0001620 SK-N-SH cell
article
Reference: Winslow AR et al.(2010) alpha-Synuclein impairs macroautophagy: implications for Parkinsons disease. J. Cell Biol. 190: 1023-1037 [PMID: 20855506]

Interaction Information:

Comment Overexpression of wild-type alpha-synuclein inhibits macroautophagy.
Formal Description
Interaction-ID: 9993

gene/protein

SNCA

decreases_activity of

process

macroautophagy

if SNCA is overexpressed
Comment Rab1a regulates autophagy. The role of Rab1a in autophagy seems to be independent of any effects of general secretion.
Formal Description
Interaction-ID: 9995

gene/protein

RAB1A

increases_activity of

process

macroautophagy

independently of the secretory pathway
Comment Rab1a knockdown and alpha-synuclein overexpression cause mislocalization of the autophagy protein Atg9.
Formal Description
Interaction-ID: 10000

gene/protein

ATG9

affects_activity of

process

macroautophagy