General Information:

Id: 1,427 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Homo sapiens
BTO:0000793 SH-SY5Y cell; neurons derived from fetal mesencephalic stem cells
article
Reference: Gandhi S et al.(2009) PINK1-associated Parkinsons disease is caused by neuronal vulnerability to calcium-induced cell death Mol. Cell 33: 627-638 [PMID: 19285945]

Interaction Information:

Comment The Na+/Ca2+ exchanger is dysfunctional in PINK1 KD neurons. The mitochondrial Ca2+ uptake capacity of control neurons was dramatically greater than PINK1 KO/KD neurons.
Formal Description
Interaction-ID: 9945

gene/protein

PINK1

affects transport of

drug/chemical compound

Ca2+

in mitochondrial