General Information:

Id: 1,427
Diseases: Parkinson disease
Homo sapiens
BTO:0000793 SH-SY5Y cell; neurons derived from fetal mesencephalic stem cells
article
Reference: Gandhi S et al.(2009) PINK1-associated Parkinsons disease is caused by neuronal vulnerability to calcium-induced cell death Mol. Cell 33: 627-638 [PMID: 19285945]

Interaction Information:

Comment PINK1 KD is associated with lowering of the basal mitochondrial membrane potential.
Formal Description
Interaction-ID: 9932

gene/protein

PINK1

affects_activity of

Comment PINK1 KD is associated with lowering of the basal mitochondrial membrane potential.
Formal Description
Interaction-ID: 9934

gene/protein

PINK1

affects_activity of

Comment In PINK1 KD neurons the calcium concentration was higher and this was associated with profound lowering of the membrane potential.
Formal Description
Interaction-ID: 9938

gene/protein

PINK1

affects_quantity of

drug/chemical compound

Ca2+

Comment In PINK1 KD neurons the calcium concentration was higher and this was associated with profound lowering of the membrane potential.
Formal Description
Interaction-ID: 9940

drug/chemical compound

Ca2+

affects_activity of

Comment PINK1 deficiency causes mitochondrial calcium overload which leads to opening of the mitochondrial permeability transition pore and mitochondrial depolarisation.
Formal Description
Interaction-ID: 9942

gene/protein

PINK1

affects_activity of

Comment The Na+/Ca2+ exchanger is dysfunctional in PINK1 KD neurons. The mitochondrial Ca2+ uptake capacity of control neurons was dramatically greater than PINK1 KO/KD neurons.
Formal Description
Interaction-ID: 9944

gene/protein

PINK1

affects_activity of

in mitochondria
Comment The Na+/Ca2+ exchanger is dysfunctional in PINK1 KD neurons. The mitochondrial Ca2+ uptake capacity of control neurons was dramatically greater than PINK1 KO/KD neurons.
Formal Description
Interaction-ID: 9945

gene/protein

PINK1

affects transport of

drug/chemical compound

Ca2+

in mitochondrial
Comment Calcium overload in PINK1 KO neurons stimulates reactive oxygen species (ROS) production via NADPH oxidase.
Formal Description
Interaction-ID: 9947

gene/protein

PINK1

affects_quantity of

drug/chemical compound

Reactive oxygen species

in mitochondria; via NADPH oxidase