General Information:

Id: 1,422 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
review
Reference: Rogers JT et al.(2008) Iron and the translation of the amyloid precursor protein (APP) and ferritin mRNAs: riboregulation against neural oxidative damage in Alzheimers disease Biochem. Soc. Trans. 36: 1282-1287 [PMID: 19021541]

Interaction Information:

Comment The essential metals iron, zinc and copper deposit near the Abeta (amyloid beta-peptide) plaques in the brain cortex of AD (Alzheimer's disease) patients.
Formal Description
Interaction-ID: 9877

drug/chemical compound

Iron

interacts (colocalizes) with

in the brain cortex of AD (Alzheimer's disease) patients
Comment Iron, in excess, is linked to neuron loss in the AD brain.
Formal Description
Interaction-ID: 9889

drug/chemical compound

Iron

affects_activity of

phenotype

neurodegeneration

Comment Iron is localized in Haem.
Formal Description
Interaction-ID: 9893

drug/chemical compound

Iron

is localized in

drug/chemical compound

Heme

Drugbank entries Show/Hide entries for
Comment Iron and copper significantly enhanced the toxicity of Abeta in cultured neural cells.
Formal Description
Interaction-ID: 9894

drug/chemical compound

Iron

increases_activity of

phenotype

amyloidosis

in cultured neural cells
Comment Neurofibrillary tangles that are the second major hallmark of AD are negatively charged and capable of binding iron, which promotes further neurotoxicity during disease progression.
Formal Description
Interaction-ID: 9898

drug/chemical compound

Iron

interacts (colocalizes) with