General Information:

Id: 1,414
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
article
Reference: Kern PA et al.(2003) Adiponectin expression from human adipose tissue: relation to obesity, insulin resistance, and tumor necrosis factor-alpha expression Diabetes 52: 1779-1785 [PMID: 12829646]

Interaction Information:

Comment A significant gender difference in adiponectin expression was observed: at similar degrees of body fat, women demonstrated considerably higher plasma adiponectin levels than men, although this difference was less apparent with obesity and high body fat levels.
Formal Description
Interaction-ID: 9737

phenotype

sex

affects_expression of

gene/protein

ADIPOQ

Comment Plasma adiponectin had a strong association with insulin sensitivity index that was not affected by sex, but no relation with insulin secretion.
Formal Description
Interaction-ID: 9741

gene/protein

ADIPOQ

affects_activity of

no gender difference
Comment Plasma adiponectin had a strong association with insulin sensitivity index that was not affected by sex, but no relation with insulin secretion.
Formal Description
Interaction-ID: 9742

gene/protein

ADIPOQ

NOT affects_activity of

Comment Adiponectin expression was not related to plasma levels of leptin or interleukin-6.
Formal Description
Interaction-ID: 9743

gene/protein

ADIPOQ

NOT affects_quantity of

gene/protein

LEP

in blood
Comment Adiponectin expression was not related to plasma levels of leptin or interleukin-6.
Formal Description
Interaction-ID: 9744

gene/protein

ADIPOQ

NOT affects_quantity of

gene/protein

IL6

in blood
Drugbank entries Show/Hide entries for IL6
Comment There was a significant inverse correlation between plasma adiponectin and tumor necrosis factor (TNF)-alpha mRNA expression, and subjects with the highest levels of adiponectin mRNA expression secreted the lowest levels of TNF-alpha from their adipose tissue in vitro.
Formal Description
Interaction-ID: 9745

gene/protein

ADIPOQ

decreases_expression of

gene/protein

TNF

Drugbank entries Show/Hide entries for TNF