General Information:

Id: 1,412 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Homo sapiens
BTO:0004419 dermal fibroblast
article
Reference: Rakovic A et al.(2010) Effect of endogenous mutant and wild-type PINK1 on Parkin in fibroblasts from Parkinson disease patients Hum. Mol. Genet. 19: 3124-3137 [PMID: 20508036]

Interaction Information:

Comment Under basal conditions, Parkin was localized in the cytosol in both controls and PINK1 mutants (Q456X, V170G). Treatment with valinomycin or H2O2 resulted in mitochondrial translocation of Parkin in controls but not in PINK1 mutants.
Formal Description
Interaction-ID: 9780

drug/chemical compound

H2O2

increases_transport of

gene/protein

PARK2

into mitochondria