General Information:

Id: 1,377 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Guglielmotto M et al.(2010) Oxidative stress mediates the pathogenic effect of different Alzheimers disease risk factors Front Aging Neurosci 2: 3 [PMID: 20552043]

Interaction Information:

Comment It has been found that the phenoxy radical of Abeta Tyr-10 produced by the reaction with ROS causes neurotoxicity and results in the formation of dityrosines which, in turn, accelerate the aggregation of Abeta peptides.
Formal Description
Interaction-ID: 9527

drug/chemical compound

Reactive oxygen species

increases_quantity of

Comment Hypoxia increases ROS via the mitochondrial transport chain and specifically by the function of complex III.
Formal Description
Interaction-ID: 9773

phenotype

hypoxia

increases_quantity of

drug/chemical compound

Reactive oxygen species

via the mitochondrial transport chain, specifically by the function of complex III