General Information:

Id: 1,377 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Guglielmotto M et al.(2010) Oxidative stress mediates the pathogenic effect of different Alzheimers disease risk factors Front Aging Neurosci 2: 3 [PMID: 20552043]

Interaction Information:

Comment Several studies have shown that protein oxidation also increases exponentially with brain aging and is associated with a decreased capacity of the antioxidative defense machinery.
Formal Description
Interaction-ID: 9458

process

aging

increases_activity of

Comment Several studies have shown that protein oxidation also increases exponentially with brain aging and is associated with a decreased capacity of the antioxidative defense machinery.
Formal Description
Interaction-ID: 9459

process

aging

decreases_activity of

Comment AD is classified into two forms: sporadic AD, which is correlated to aging, and a rare familial earlyonset AD (FAD), caused by gene mutations.
Formal Description
Interaction-ID: 9460

process

aging

increases_activity of

Comment OS results from several cellular insults such as aging, hyperglycemia, hypoxic insults that are all well known risk factors for AD development.
Formal Description
Interaction-ID: 9461

process

aging

increases_activity of

Comment Mitochondrial mutations accumulate during brain aging and neurodegenerative diseases. Mutations in mitochondrial DNA cause a respiratory chain dysfunction, which can increase cellular OS.
Formal Description
Interaction-ID: 9635

process

aging

increases_activity of

brain aging increases mitochondrial mutations