General Information:

Id: 1,365 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Mus musculus
BTO:0000944 NIH-3T3 cell
article
Reference: Kabuta T et al.(2008) Aberrant interaction between Parkinson disease-associated mutant UCH-L1 and the lysosomal receptor for chaperone-mediated autophagy J. Biol. Chem. 283 [PMID: 18550537]

Interaction Information:

Comment UCH-L1 I93M causes accumulation of alpha-synuclein due to inhibition of CMA-dependent degradation.
Formal Description
Interaction-ID: 9339

process

autophagy

decreases_quantity of

gene/protein

SNCA