General Information:

Id: 1,360 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Homo sapiens
BTO:0000793 SH-SY5Y cell
article
Reference: Kyratzi E et al.(2008) The S18Y polymorphic variant of UCH-L1 confers an antioxidant function to neuronal cells Hum. Mol. Genet. 17: 2160-2171 [PMID: 18411255]

Interaction Information:

Comment S18Y mutant, but not WT, UCH-L1 reduced ROS generation after treatment with MPTP or H2O2.
Formal Description
Interaction-ID: 9309

increases_quantity of

drug/chemical compound

Reactive oxygen species

Comment S18Y mutant, but not WT, UCH-L1 reduced ROS generation after treatment with MPTP or H2O2.
Formal Description
Interaction-ID: 9310

gene/protein

UCHL1

NOT decreases_quantity of

drug/chemical compound

Reactive oxygen species

after treatment with MPTP
Comment S18Y mutant, but not WT, UCH-L1 reduced ROS generation after treatment with MPTP or H2O2.
Formal Description
Interaction-ID: 9311

gene/protein mutant

UCHL1-p.S18Y

decreases_quantity of

drug/chemical compound

Reactive oxygen species

after treatment with MPTP