General Information:

Id: 1,357 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
Wild-type (WT), CX3CR1-EGFP, Nox1, and gp91phox/Nox2 knock-out (KO) mice
BTO:0000078 microglia
article
Reference: Cheret C et al.(2008) Neurotoxic activation of microglia is promoted by a nox1-dependent NADPH oxidase. J. Neurosci. 28 [PMID: 19005069]

Interaction Information:

Comment Comparisons of LPS-treated microglia purified from WT, Nox2-KO, or Nox1-KO mice indicate that both Nox1 and Nox2 are required to optimize microglial production of nitric oxide.
Formal Description
Interaction-ID: 9277

gene/protein

NOX1

increases_quantity of

drug/chemical compound

NO

in microglia; induced by LPS
Comment Comparisons of LPS-treated microglia purified from WT, Nox2-KO, or Nox1-KO mice indicate that both Nox1 and Nox2 are required to optimize microglial production of nitric oxide.
Formal Description
Interaction-ID: 9278

gene/protein

CYBB

increases_quantity of

drug/chemical compound

NO

in microglia; induced by LPS