General Information:

Id: 1,356 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Mus musculus
Reference: Perier C et al.(2005) Complex I deficiency primes Bax-dependent neuronal apoptosis through mitochondrial oxidative damage Proc. Natl. Acad. Sci. U.S.A. 52 [PMID: 16365298]

Interaction Information:

Comment ROS generated by complex I inhibition with MPTP oxidize the inner mitochondrial lipid cardiolipin. Oxidative modifications of cardiolipin induce the release of cytochrome c from the inner mitochondrial membrane.
Formal Description
Interaction-ID: 9280

increases_quantity of

drug/chemical compound

Reactive oxygen species

in mitochondria