General Information:

Id: 1,349 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mus musculus
primary neuronal cultures from wild-type (WT) and PS1 null (PS1-/-) embryonic mouse brains
article
Reference: Baki L et al.(2008) Wild-type but not FAD mutant presenilin-1 prevents neuronal degeneration by promoting phosphatidylinositol 3-kinase neuroprotective signaling J. Neurosci. 28: 483-490 [PMID: 18184791]

Interaction Information:

Comment Wild-type but not FAD mutant presenilin-1 prevents neuronal degeneration by promoting phosphatidylinositol 3-kinase (PI3K) neuroprotective signaling.
Formal Description
Interaction-ID: 9254

gene/protein

PSEN1

decreases_activity of

phenotype

neurodegeneration