General Information:

Id: 1,349
Diseases: Alzheimer disease - [OMIM]
Mus musculus
primary neuronal cultures from wild-type (WT) and PS1 null (PS1-/-) embryonic mouse brains
article
Reference: Baki L et al.(2008) Wild-type but not FAD mutant presenilin-1 prevents neuronal degeneration by promoting phosphatidylinositol 3-kinase neuroprotective signaling J. Neurosci. 28: 483-490 [PMID: 18184791]

Interaction Information:

Comment Wild-type but not FAD mutant presenilin-1 prevents neuronal degeneration by promoting phosphatidylinositol 3-kinase (PI3K) neuroprotective signaling.
Formal Description
Interaction-ID: 9220

gene/protein

PSEN1

increases_activity of

Comment Wild-type but not FAD mutant presenilin-1 prevents neuronal degeneration by promoting phosphatidylinositol 3-kinase (PI3K) neuroprotective signaling.
Formal Description
Interaction-ID: 9254

gene/protein

PSEN1

decreases_activity of

phenotype

neurodegeneration

Comment Wild-type but not FAD mutant presenilin-1 prevents neuronal degeneration by promoting phosphatidylinositol 3-kinase (PI3K) neuroprotective signaling.
Formal Description
Interaction-ID: 9255

decreases_activity of

phenotype

neurodegeneration

Comment Wild-type but not FAD mutant PS1 null (PS1-/-) prevents neuronal degeneration by promoting phosphatidylinositol 3-kinase (PI3K) neuroprotective signaling.
Formal Description
Interaction-ID: 9256

gene/protein

PSEN1

affects_activity of

phenotype

neurodegeneration

Comment Wild-type but not FAD mutant PS1 null (PS1-/-) prevents neuronal degeneration by promoting phosphatidylinositol 3-kinase (PI3K) neuroprotective signaling.
Formal Description
Interaction-ID: 9257

gene/protein mutant

PSEN1-mut

increases_activity of

Comment Mature PS1-/- neurons show increased activation of apoptotic caspase-3.
Formal Description
Interaction-ID: 9297

gene/protein

PSEN1

affects_activity of

gene/protein

CASP3

Drugbank entries Show/Hide entries for CASP3