General Information:

Id: 1,348 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mus musculus
CA1- and CA3-PS cDKO mice containing homozygous floxed PS1 alleles, homozygous PS2-/- alleles and Camk2a-Cre and KA1-Cre transgene
article
Reference: Zhang C et al.(2009) Presenilins are essential for regulating neurotransmitter release Nature 460: 632-636 [PMID: 19641596]

Interaction Information:

Comment Presenilins show an essential role in the activity-dependent regulation of neurotransmitter release and long-term potentiation (LTP) induction via modulation of intracellular Ca2+-release in presynaptic terminals.
Formal Description
Interaction-ID: 9200

gene/protein

PSEN1

affects_activity of

Comment Presenilins show an essential role in the activity-dependent regulation of neurotransmitter release and long-term potentiation (LTP) induction via modulation of intracellular Ca2+-release in presynaptic terminals.
Formal Description
Interaction-ID: 9209

gene/protein

PSEN1

affects_activity of

Comment Presenilin is involved in the regulation of Ca2+ homeostasis.
Formal Description
Interaction-ID: 9210

gene/protein

PSEN1

affects_activity of

Comment Presynaptic but not postsynaptic inactivation of presenilins alters short-term plasticity and synaptic facilitation.
Formal Description
Interaction-ID: 9211

gene/protein

PSEN1

affects_activity of

Comment Presenilins show an essential role in the activity-dependent regulation of neurotransmitter release and long-term potentiation (LTP) induction via modulation of intracellular Ca2+-release in presynaptic terminals.
Formal Description
Interaction-ID: 9212

gene/protein

PSEN1

affects_activity of

Comment Presynaptic but not postsynaptic inactivation of presenilins alters short-term plasticity and synaptic facilitation.
Formal Description
Interaction-ID: 9213

gene/protein

PSEN1

affects_activity of

Comment Mutations in the presenilin genes are the major cause of familial Alzheimer disease (AD).
Formal Description
Interaction-ID: 9218

gene/protein mutant

PSEN1-mut

affects_activity of

gene/protein

PSEN1