General Information:

Id: 1,348 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mus musculus
CA1- and CA3-PS cDKO mice containing homozygous floxed PS1 alleles, homozygous PS2-/- alleles and Camk2a-Cre and KA1-Cre transgene
Reference: Zhang C et al.(2009) Presenilins are essential for regulating neurotransmitter release Nature 460: 632-636 [PMID: 19641596]

Interaction Information:

Comment Presenilins show an essential role in the activity-dependent regulation of neurotransmitter release and long-term potentiation (LTP) induction via modulation of intracellular Ca2+-release in presynaptic terminals.
Formal Description
Interaction-ID: 9200



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