General Information:

Id: 1,346 (click here to show other Interactions for entry)
Diseases: Disease-related-protein CtBP
Homo sapiens
BTO:0002552 NCI-H1299 cell; BTO:0000182 HT-29 cell
article
Reference: Zhang Q et al.(2006) Redox sensor CtBP mediates hypoxia-induced tumor cell migration Proc. Natl. Acad. Sci. U.S.A. 103: 9029-9033 [PMID: 16740659]

Interaction Information:

Comment Hypoxia increases free NADH levels, which promotes CtBP recruitment to the E-cadherin promoter, repressing E-cadherin gene expression and increasing tumor cell migration.
Formal Description
Interaction-ID: 9179

process

response to hypoxia

increases_quantity of

drug/chemical compound

NADH

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