General Information:

Id: 1,344 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mammalia
SOD1 wt or SOD1G93A transgenic mouse, transfected with human wt SOD1 or human SOD1G93A
microglia (mouse) / motoneuron (rat) co-cultures
article
Reference: Xiao Q et al.(2007) Mutant SOD1(G93A) microglia are more neurotoxic relative to wild-type microglia J. Neurochem. 102: 2008-2019 [PMID: 17555556]

Interaction Information:

Comment More nitric oxide and less IGF-1 were detected in mSOD1(G93A) microglia co-cultured with motoneurons (mSOD1G93A-Mc + MN) than wild-type microglia co-cultured with motoneurons.
Formal Description
Interaction-ID: 9166

gene/protein mutant

SOD1-p.G93A

increases_quantity of

drug/chemical compound

NO

in microglia/motoneuron co-cultures
Comment There was a strong inverse correlation between the level of nitric oxide release and motoneuron injury. The more nitrate + nitrite produced, the fewer motoneuron survived in mSOD1G93A and wild-type-co-cultures.
Formal Description
Interaction-ID: 9170

drug/chemical compound

NO

increases_activity of

in microglia/motoneuron co-cultures