General Information:

Id: 1,343 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
SOD1 wt or SOD1G93A transgenic mouse, transfected with human wt SOD1 or human SOD1G93A
BTO:0000078 microglia
article
Reference: Xiao Q et al.(2007) Mutant SOD1(G93A) microglia are more neurotoxic relative to wild-type microglia J. Neurochem. 102: 2008-2019 [PMID: 17555556]

Interaction Information:

Comment Mutant mSOD1(G93A) microglia are more responsive to stimuli than wild-type microglia. Following activation with lipopolysaccharide (LPS), mSOD1(G93A) microglia released more nitric oxide, more superoxide, and less insulin-like growth factor-1 than wild-type microglia.
Formal Description
Interaction-ID: 9162

gene/protein mutant

SOD1-p.G93A

increases_quantity of

drug/chemical compound

NO

in microglia; induced by LPS
Comment Microglial activation can be associated with increased production of potentially cytotoxic substances, such as nitric oxide, superoxide, and pro-inflammatory cytokines.
Formal Description
Interaction-ID: 9171

drug/chemical compound

NO

affects_activity of