General Information:

Id: 13,368 (click here to show other Interactions for entry)
Diseases: Hematological
Homo sapiens
article
Reference: Urano T et al.(2019) Recognition of Plasminogen Activator Inhibitor Type 1 as the Primary Regulator of Fibrinolysis Curr Drug Targets 20: 1695-1701 [PMID: 31309890]

Interaction Information:

Comment The fibrinolytic system consists of a balance between rates of plasminogen activation and fibrin degradation, both of which are finely regulated by spatio-temporal mechanisms. Three distinct inhibitors of the fibrinolytic system that differently regulate these two steps are plasminogen activator inhibitor type-1 (PAI-1), ?2-antiplasmin, and thrombin activatable fibrinolysis inhibitor (TAFI).
Formal Description
Interaction-ID: 126031

gene/protein

Thrombin

affects_activity of

process

fibrinolysis